Protein Alignment nAChRbeta1 and lgc-12

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_498656.3
• Gene: lgc-12 / 187855
• WormBaseID: WBGene00020048
• Length: 428
• Species: Caenorhabditis elegans
• Alignment Length: 354
• Identity: 102/354 - (28%)
• Similarity: 175/354 - (49%)
• Gaps: 42/354 - (11%)

  Fly    27 DEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQW 91
            :|..||:.|.:.|.:..|||:|.:..:.|........|:.|||:|:.:|..:|....|.|..|.|
 Worm    28 NERELVKHLMKDYYQFTRPVKNYSSMLTVTIMPQIYNLVEVNEQNEQIKLLIWFPQSWKDDYLVW 92

  Fly    92 DEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDV 156
            |..::.||..:.:|...||.||..:||..: ..:.....||.::..|:|......:....|.:.|
 Worm    93 DPDEWDGIEKITIPKSMVWLPDGYIFNTVE-ETDTLDNHNVRVHYNGKVEVDFNKLIDLICPMSV 156

  Fly   157 TYFPFDQQTCIMKFGSWTFNGDQVSL----ALYNNKNFVDLSDYWKSGTWDII------EVPAYL 211
            ..||||.|.|.::|||||:....:|.    |..|..|        |:..|||:      :|..|:
 Worm   157 LSFPFDVQLCALQFGSWTYQSHALSFNVLEASVNENN--------KNSEWDIVAFNATKKVSKYM 213

  Fly   212 NVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLP----AEAGEKVTLGI 272
            |:..||:.:   .:|.:::.:|||.|:|.|.:::||.||..:..:..:.|    .:..|.|:||:
 Worm   214 NLIGGDNVY---EEIFYFLEVRRKPLYYIVVILIPTFLIVTVSNIGLFTPHGVHGDREEHVSLGL 275

  Fly   273 SILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYI 337
            :.:|::.|.|.:|:..:|.:|..:||:..|:|..|.::.:::||:|:||       ..|.
 Worm   276 TTMLTMAVILDMVTGQMPKSSEGIPLLGMYVLIEFALSIMAVLVSVLII-------FAHE----- 328

  Fly   338 RSIFLHYLPAF----LFMKRPRKTRLRWM 362
            |.:::..:|.|    ||.|...:..|..|
 Worm   329 RMLYMDAMPPFWIFRLFSKHKNQIPLAEM 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	102/354 (29%)
		Neur_chan_LBD	28..236	CDD:280998	64/217 (29%)
		Neur_chan_memb	243..498	CDD:280999	34/128 (27%)
lgc-12	NP_498656.3	Neur_chan_LBD	29..235	CDD:280998	64/217 (29%)
		Neur_chan_memb	242..>345	CDD:280999	29/114 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810