Protein Alignment nAChRbeta1 and acr-20

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001367183.1
• Gene: acr-20 / 187632
• WormBaseID: WBGene00000059
• Length: 556
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 144/562 - (25%)
• Similarity: 245/562 - (43%)
• Gaps: 105/562 - (18%)

  Fly    12 SILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKS 76
            ::|:|.:..|::.|.|:..:...:...||..:.|.......:.|.|.:...|:|:|||..|.:..
 Worm     8 AVLLLHSLVLLTVSSDQYEIANKILDKYNAGLIPSMGKKSPIEVHFSMELYQIISVNEPQQFLML 72

  Fly    77 NVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNA----DGNYEVRY-KSNVLIYP 136
            |.|:...|.|..|.||...:|.:..:.||...:|.||..|:|:.    |.|..:.: |...|...
 Worm    73 NAWVVERWTDRLLGWDPEKFGNVTEIMLPHHFIWLPDTTLYNSLVMKDDENRRLLHAKVTTLGEG 137

  Fly   137 TG---EVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWK 198
            .|   |:|:  |.||:.||.:::.:||||.|:|.:.||||||:..::....:|....:..::..:
 Worm   138 NGAFIELLY--PTIYKLSCLLNLRFFPFDVQSCRLLFGSWTFDNTKIDYFAFNESQAIGTTNCIE 200

  Fly   199 SGTWDII--EVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYL- 260
            :..|:::  .|..:.|.|:...|:  .|.:.|.:.|:||.|:|.:|||:||.:|:|:.::.|:.
 Worm   201 NEGWNVLSTSVIRHENKYDCCPNN--YTLLEFRLTIQRKPLYYIINLIIPTSIITFISIIGFFST 263

  Fly   261 -----PAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVII 320
                 |.|  ||:||||:.|||:.:.:.:||..:|.||..:|||..:.....::.:.|.:.:.::
 Worm   264 SSINEPRE--EKITLGITTLLSMSILIFMVSDKMPSTSSFIPLIGLFYTSMILLISFSTICSSVV 326

  Fly   321 I----NWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSP 381
            |    ..|...|                 |:..||...|.......||||.:...|     |...
 Worm   327 IYVQKQGNLGNP-----------------PSKNFMNIARAVNRFIRMEMPLIMKQA-----YAQK 369

  Fly   382 AELPK-HISAIGGKQS------KM--------------------EVM---ELSDLHHPNCKINRK 416
            |...| ....:|.|||      |:                    ||:   :|.|.....|.||:.
 Worm   370 AREEKLRRQQMGRKQSLWTRVYKLAREQALRKDVQTSQNSSKFNEVLTPEKLIDNGGKRCTINKD 434

  Fly   417 V---NSGGELGLG-DGCRRESESSDSILLSPEAS------------KATEAVEFIAEHLRNEDLY 465
            |   :..|.:.:| .....|.:..|..||..|.:            ||:....|.:...|..::.
 Worm   435 VTCISDSGIVAMGVPTLASEDDDQDVSLLELETTPTPAMQRPTRLHKASTCGSFDSMMFRQIEVP 499

  Fly   466 IQTRE---------DWKYVAMVIDRLQLYIFFIVTTAGTVGI 498
            :..|.         ||  :|.:::|:.|..|..:....::||
 Worm   500 VSPRTARNLAEIEYDW--LAALLERIFLITFLFIFVLTSIGI 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	144/562 (26%)
		Neur_chan_LBD	28..236	CDD:280998	60/217 (28%)
		Neur_chan_memb	243..498	CDD:280999	73/319 (23%)
acr-20	NP_001367183.1	Neur_chan_LBD	24..238	CDD:397192	60/217 (28%)
		LGIC_TM_cation	239..>329	CDD:349853	31/91 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910