Protein Alignment nAChRbeta1 and lgc-30

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_500015.3
• Gene: lgc-30 / 186551
• WormBaseID: WBGene00019069
• Length: 529
• Species: Caenorhabditis elegans
• Alignment Length: 503
• Identity: 109/503 - (21%)
• Similarity: 210/503 - (41%)
• Gaps: 110/503 - (21%)

  Fly    45 PVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKV 109
            |:::...::.|.......|:::::::|.:...:.:|.:.|.|..::|....:|||..:.:|...:
 Worm    82 PLKHPHTRIDVFISAGLYQIVDLDQRNNLATVSAYLDVHWNDDFIKWKPEIFGGIERIFVPIKWI 146

  Fly   110 WKPDIVLFNNA---------DGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQT 165
            |||:..::::.         |.:.|:.|...|.::.:        ...:|.|.|:...||||.||
 Worm   147 WKPEFYMYHSVYGRVPDYAPDASAELHYNGLVRMFVS--------ISSKSFCPINFKRFPFDSQT 203

  Fly   166 CIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYI 230
            |....|||.:..:.|:|..  .|..:.|.|::.:..|.:.:.    .::.|.:.:.:..:.:|.:
 Worm   204 CSFSCGSWAYQSNIVNLVA--AKQEIALEDFYDNQEWLLTDA----RLFNGTTRNVSAANESFSM 262

  Fly   231 I-----IRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA----GEKVTLGISILLSL-VVFLLLV 285
            :     ::|::.:|..||:.||.|:|.:.|:.|:.|..|    ..|..|||..|||: |:.|:||
 Worm   263 VYMQLDLKRQSFYYVFNLVFPTTLVSLVAVIGFHAPINATGRRESKFRLGIMTLLSMSVMLLMLV 327

  Fly   286 SKILPPTSLV---------LPLIAKYLLFTFIMNTVSILVTVIIIN---WNFRGPRTHRMPMYIR 338
            .::......|         :||:..|.:....:.:::...:.|.::   :..|.|....:|.|||
 Worm   328 GEMKFAMESVPGQRGSFSDVPLMGIYYMTLICIVSIATCTSSIFVHLEKFALRNPSWQSVPWYIR 392

  Fly   339 -----SIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAEL-PKHISAIGGKQSK 397
                 .:|..|:|     |..|..:..:.......::..|..|.......| ||.|:.
 Worm   393 WLAAKKLFCCYVP-----KSFRYDKDAYSRNNNVQAISLHSTPDRNVAKNLIPKEINF------- 445

  Fly   398 MEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNE 462
            .||.:.:.||                              .:|..|.|.| |:.::.|...|| |
 Worm   446 TEVNQDAPLH------------------------------DVLEGPSAEK-TQKIDLIVSLLR-E 478

  Fly   463 DLYIQTR-----EDWKYVAMVIDR-----LQLYIFFIVTTAGTVGILM 500
            .::::.|     :...|...:|.|     |..|:|.|     |:.:||
 Worm   479 IIHLKERIGASGQLAPYWDQIISRCEKVSLSFYLFLI-----TINVLM 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	107/501 (21%)
		Neur_chan_LBD	28..236	CDD:280998	41/204 (20%)
		Neur_chan_memb	243..498	CDD:280999	64/287 (22%)
lgc-30	NP_500015.3	Neur_chan_LBD	68..272	CDD:367255	40/203 (20%)
		LGIC_TM_cation	274..>374	CDD:349853	27/99 (27%)
		TM1 helix	278..298	CDD:349853	8/19 (42%)
		TM2 helix	310..338	CDD:349853	10/27 (37%)
		TM3 helix	352..374	CDD:349853	2/21 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810