DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta1 and acr-21

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001355512.1	Gene:	acr-21 / 185004	WormBaseID:	WBGene00000060	Length:	635	Species:	Caenorhabditis elegans

Alignment Length:	622	Identity:	175/622 - (28%)
Similarity:	281/622 - (45%)	Gaps:	153/622 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQ 88
            |.::..||.|||...||..:||..:..:.:.|.|..:..|:|:|:|:|||:.:|.|:||.|.||:
Worm    27 ADQNVMRLYRDLLYDYNNEVRPSVHSKEPINVTFVFSLTQIIDVDERNQILTTNSWIRLHWVDYK 91

  Fly    89 LQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKS-NVLIYPTGEVLWVPPAIYQSSC 152
            |.||...|..:..:.:|.||:|||||:|:||||..|.....| :|::...|.:.|...||:.|||
Worm    92 LVWDPRLYQNVTRIHIPSDKIWKPDIILYNNADAQYMKSVMSTDVIVDYLGNIHWPLSAIFTSSC 156

  Fly   153 TIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLN--VYE 215
            .:||.::|||:||||:|:.||.::|.::.|.|.:.:.  ||::|..:..|.:|.:.|..|  :|.
Worm   157 PLDVKHYPFDRQTCILKYASWAYDGTKIDLLLKSEQG--DLTNYITNTEWSLIGIRAEKNQVIYS 219

  Fly   216 -GDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLV 279
             ....:|.   |..::.|.|:.:||..|||||.||||.:.::.||:|.::||||||||:.|||..
Worm   220 CCPEPYPF---IDVHVTIERRAMFYVFNLILPCVLISLIALMGFYMPTDSGEKVTLGITSLLSTT 281

  Fly   280 VFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHY 344
            |||::|::.:|||:..||||..|...|.::..:...:||..:|.:..|...:.:|.:::.....|
Worm   282 VFLMMVAEGMPPTAEALPLIGIYFGVTIMLVALGTAMTVFTVNIHHTGVHGYPVPPFLQIFAFRY 346

  Fly   345 LPAFLFMK------------------RPRKTRL--------------------------RWMMEM 365
            |...||::                  .|.:..|                          |.|..:
Worm   347 LSKILFVRIEPYHSIAHHVRYMYQKEHPTECTLSASVHYKRLHDFDANVAKKEEQYGLQRDMSNL 411

  Fly   366 PGMSMPAHPHPS------------------------------YGSPAELPK---HISAIGGKQSK 397
            ..:|...|.:|.                              .|||....|   .:|.|......
Worm   412 SVISANVHCNPDDRLLLGSQSSQKNLNKFDSEKNLRSSLSIRSGSPTAKKKGHVRVSNIARSTRI 476

  Fly   398 ME-----VMELSDLHHPNCKIN-----RKV-------------NSGGELGLGDGCRRESESSDSI 439
            ||     ::..|.|:.....|:     ||:             ||.|..|:         :||.:
Worm   477 METDVSHLVSFSSLNSHGTPIDSPIYGRKLGRTQSQTPTSSYRNSNGNGGI---------TSDPL 532

  Fly   440 ---LLSPEASKATE--------------AVEFIAEHLR----------NEDLYIQTRE------- 470
               |.:|.....|:              ..||..|.||          ..::.:..::
Worm   533 PQQLSNPPKISLTDVDDVFENNENQQPMVDEFEKEFLRVMSMVHGIIERNEMRVAEKDKRDAIAL 597

  Fly   471 DWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFE 507
            :|:.||||:||..|.:|.|.|:..|. ::::..::||
Worm   598 EWQQVAMVLDRFLLVVFLIGTSMSTF-VILNQRNLFE 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	173/613 (28%)
		Neur_chan_LBD	28..236	CDD:280998	79/211 (37%)
		Neur_chan_memb	243..498	CDD:280999	90/388 (23%)
acr-21	NP_001355512.1	LGIC_ECD_nAChR	56..237	CDD:349798	69/185 (37%)
		Cys-loop	156..170	CDD:349798	7/13 (54%)
		LGIC_TM_cation	239..>327	CDD:349853	41/87 (47%)
		TM1 helix	239..263	CDD:349853	13/23 (57%)
		TM2 helix	271..292	CDD:349853	11/20 (55%)
		TM3 helix	303..325	CDD:349853	4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810