Protein Alignment nAChRbeta1 and lgc-31

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001256671.1
• Gene: lgc-31 / 184752
• WormBaseID: WBGene00008997
• Length: 675
• Species: Caenorhabditis elegans
• Alignment Length: 545
• Identity: 129/545 - (23%)
• Similarity: 231/545 - (42%)
• Gaps: 98/545 - (17%)

  Fly    30 RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNE-KNQIMKSNVWLRLVWYDYQLQWDE 93
            ||..||.|.|.|..|||.:..:.:.|...:...|::.::. ||.|..|..: .|.|.|..|:|:.
 Worm   130 RLHDDLLRYYRKGTRPVTHPKKVISVSMSVFLYQIVKLDAVKNTISLSGSF-ELYWEDEFLKWNP 193

  Fly    94 ADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSN--VLIYPTGEVLWVPPAIYQSSCTIDV 156
            :.|.|...:.|....:|.|:..|:.:.:.|..|:.:||  |.:..||:|.:..|...:|.|.:||
 Worm   194 SSYEGAEEIFLSSSDIWIPEFSLYYSLNFNDAVKLQSNNDVRVNYTGQVRYYIPFSSESLCKLDV 258

  Fly   157 TYFPFDQQTCIMKFGSWTFNGDQVSLALYN-NKNFVDLSD--YWKSGT-----------WDIIEV 207
            .:||||.|.|.:.||||..:.|.:..:||: |.:.:|..|  .|:..|           :|.::.
 Worm   259 KFFPFDVQQCSLLFGSWAHSNDSIKYSLYSQNLSLIDFYDNQEWELDTHNSSVHSDGFLYDYLDP 323

  Fly   208 PAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGE----KV 268
            |.:..:            |...::::|::.:|..||::|:.:|:.:.|:.|:.|:.:|.    |.
 Worm   324 PLFWEM------------IIITLVMKRQSFYYVFNLVIPSTMITLVSVIGFHTPSTSGRMRDAKF 376

  Fly   269 TLGISILLSLVVFLLLVSKILPPTSL-----------VLPLIAKYLLFTFIMNTVSILVTVIIIN 322
            .|||..|:|:.|.||.:.:.:|..|:           .:|||..|......:..:|.:.|.:.:.
 Worm   377 RLGIMTLMSMSVILLAIVEDMPKFSMGTNRRGRGSFSGIPLIGLYYFILLAIIGMSTVTTSMFVY 441

  Fly   323 WNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAE---- 383
            ..........:|.|::.:.....|:.:..|..| .|.:.|.:.|...:.::.|...|...:
 Worm   442 LERESRVKMNVPWYLKWLSFDISPSKIARKLSR-YRPQAMSQPPSEHLLSNGHVRSGIRDKARGV 505

  Fly   384 -------LPKHISAIG-------GKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESE 434
                   ||:..|.:|       ...|...:..|...|..|....|           :..||...
 Worm   506 AASLLSLLPRPGSGVGNGGPGGDNGNSPFHMQHLHAYHQDNPTPAR-----------ESIRRRLS 559

  Fly   435 SS--DSILLSPEASKATEAVE--------FIAEHLRNEDLYIQTRED----WKYVAMVIDRLQLY 485
            .|  |::|:.....:|.|.:.        .||| :|:|.:....::|    |:.|...::.|.|:
 Worm   560 MSQYDNMLIYQYYEQALEDIANGVSRMAGSIAE-IRSEMMAFLPQDDINTKWQTVIRRLEILSLF 623

  Fly   486 IFFIVTTAGTVGILMDAPHIFEYVD 510
            .:        |.:|....::|.|.|
 Worm   624 FY--------VSVLFTTMYLFFYHD 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	125/533 (23%)
		Neur_chan_LBD	28..236	CDD:280998	62/222 (28%)
		Neur_chan_memb	243..498	CDD:280999	61/301 (20%)
lgc-31	NP_001256671.1	TM_EphA1	<43..>79	CDD:391457
		LGIC_ECD_cation	153..339	CDD:349790	51/198 (26%)
		LGIC_TM_cation	341..>442	CDD:349853	26/100 (26%)
		TM1 helix	345..365	CDD:349853	6/19 (32%)
		Neur_chan_memb	347..634	CDD:367256	62/307 (20%)
		TM2 helix	377..398	CDD:349853	8/20 (40%)
		TM3 helix	420..442	CDD:349853	3/21 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910