Protein Alignment nAChRbeta1 and lgc-5

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_501411.4
• Gene: lgc-5 / 184620
• WormBaseID: WBGene00017543
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 365
• Identity: 82/365 - (22%)
• Similarity: 170/365 - (46%)
• Gaps: 49/365 - (13%)

  Fly     7 SWLLCSI---LVLVAF--SLVSASEDEERLVRDLF-RGYNKLIRPVQNMTQKVGVRFGLAFVQLI 65
            ||||.|:   |||..|  :..:...:.|.|:::|| |.|:..::|...:|.   |........|:
 Worm     2 SWLLNSLLTFLVLRTFGSNTTNVESNTEVLLQELFNRTYDVNVKPSDTLTT---VTITPNTFLLL 63

  Fly    66 NVNEKNQIMKSNVWLRLVWYDYQLQWDEA--DYGGIGVLRLPPDKVWKPDIV---------LFNN 119
            ::::..:.:..:....|.|||..|.|:..  ||....: ::...:||.||::         |.:.
 Worm    64 SMDQTQETILFSQEFLLKWYDPILHWNRTLFDYNREWI-KISVSRVWVPDVIFTKRLSVESLLDE 127

  Fly   120 ADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL 184
            .....::||        .||:....||:..:||.:::..||.|.|.|.:..|||.|  |:..:.:
 Worm   128 DMQMADLRY--------NGEIRTSLPAVVSTSCPLNIQDFPHDVQECNISMGSWAF--DRTVIVV 182

  Fly   185 YNN-KNFVDLSDYWKSGT-WDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPT 247
            .:: ...:.|...::..: |:::.:.|:.......|...:.::||:.:.::||.::|.:.:..||
 Worm   183 QSSVDEILPLRGRFEGNSEWELLSIRAFRTDSFEYSLGTSFSEITYTVTLQRKPVYYVLVIQAPT 247

  Fly   248 VLISFLCVLVFYLP----AEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFI 308
            .::..:.:...:.|    .|...:|.|.:::..::.:.|.|||.::|..|. |||:..|::....
 Worm   248 FILCTITIFGLFSPNSNENERLSRVELCLNMFAAISMMLQLVSDMMPKASR-LPLLGNYIIAEIF 311

  Fly   309 MNTVSILVTVII------INWNFRGPRTHRMPMYIRSIFL 342
            :.|.:.:..::|      ::.|...|     |.::|.:.|
 Worm   312 VVTAATIAAIVIQHVHHHVHTNATCP-----PKWLRCLVL 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	81/364 (22%)
		Neur_chan_LBD	28..236	CDD:280998	48/221 (22%)
		Neur_chan_memb	243..498	CDD:280999	23/110 (21%)
lgc-5	NP_501411.4	LGIC_ECD_cation	51..235	CDD:349790	40/197 (20%)
		LGIC_TM	238..>323	CDD:365787	18/85 (21%)
		TM1 helix	238..261	CDD:349850	3/22 (14%)
		TM2 helix	273..294	CDD:349850	5/20 (25%)
		TM3 helix	304..323	CDD:349850	2/18 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810