DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta1 and lgc-25

DIOPT Version :9

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_510359.3 Gene:lgc-25 / 181525 WormBaseID:WBGene00010994 Length:502 Species:Caenorhabditis elegans


Alignment Length:541 Identity:116/541 - (21%)
Similarity:228/541 - (42%) Gaps:98/541 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLCSILVLVAF-SLVSASEDEERLVRDLFRGYNKLIRPVQN---MTQKVGVRFGLAFVQLINVNE 69
            ||..|||:... :.|.....|::|.:.|...||..:|||::   :|| |.|...:|.|:.::.:|
 Worm     7 LLIGILVIWHLDNQVCGLSKEQQLEKQLMVKYNYKVRPVKSEATVTQ-VNVFLSIAHVEKVDEHE 70

  Fly    70 KNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNV-- 132
            :..::..::|  ..|.|..:||| |....:..|.:....:|:|.:.|:|:|.||....|...:  
 Worm    71 QTALVHGHIW--ATWIDEYMQWD-AKKENVTKLTISAHSLWQPALALYNSARGNSWHLYMGAMPA 132

  Fly   133 LIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLA-LYNNKNF------ 190
            .:|.||:|.......:..:|..|.|.:|||||:|.:....|.:|.:||:|: .|..|.:      
 Worm   133 TVYSTGKVWSTGTFSFYVTCQFDFTNWPFDQQSCPIVIADWVYNLNQVNLSDPYILKEYGKPSIR 197

  Fly   191 -----VDLSDYWKSGTWDIIEV--------PAYLNVYEGDSNHPTETDITFY-------IIIRRK 235
                 ::.||......|::::.        |      :|......|.:..:|       ||:||.
 Worm   198 LSYDPIEKSDKRHVAGWEVMDAWKKHCYWGP------KGCKEEQPEGEAEWYWSLLEFGIILRRH 256

  Fly   236 TLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIA 300
            ..:::::::.|....|.:.:|.|::...:....|:.::|:|.......|::| :||.|...|.|.
 Worm   257 LPYFSLSILFPMAGTSLILLLCFWIETHSICFFTIMLNIILQSYYGSSLLAK-MPPGSGRTPKIV 320

  Fly   301 KYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEM 365
            .......:::.|..::.|.......|.|:...:.:           .|..:..|::..:..:...
 Worm   321 HLYNMNLLLSAVQFVLIVFSEFLRLRLPKKFELDL-----------GFDIIGVPQRFGVDKLFTQ 374

  Fly   366 PGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGG----ELGLG 426
            .|:|.         .|.||   .|.:...::..|::|               ..||    .:|:|
 Worm   375 KGLSF---------DPQEL---FSNVYSTRTLEEILE---------------QGGGSSSTSVGIG 412

  Fly   427 DGCRRE----SESSDSILL-------SPEASKATEAVEFIAEHLRNEDLYI-QTREDWKYVAMVI 479
            :....:    .:||||.:|       .|::..|:.:....:|...||:..| :..|:.:.:.:.:
 Worm   413 NPLHEDITSFQKSSDSSVLIDIPMTSEPQSFSASTSELLSSEPSSNEETQISEEPEEERILDVQL 477

  Fly   480 DRLQLYIFFIVTTAGTVGILM 500
            ..::.|:|.:|.....:..|:
 Worm   478 RHIKRYVFCLVIFIHIIAFLL 498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:273305 115/539 (21%)
Neur_chan_LBD 28..236 CDD:280998 62/239 (26%)
Neur_chan_memb 243..498 CDD:280999 47/270 (17%)
lgc-25NP_510359.3 LGIC_ECD_cation 52..256 CDD:349790 53/213 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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