Protein Alignment nAChRbeta1 and lgc-25

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_510359.3
• Gene: lgc-25 / 181525
• WormBaseID: WBGene00010994
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 541
• Identity: 116/541 - (21%)
• Similarity: 228/541 - (42%)
• Gaps: 98/541 - (18%)

  Fly     9 LLCSILVLVAF-SLVSASEDEERLVRDLFRGYNKLIRPVQN---MTQKVGVRFGLAFVQLINVNE 69
            ||..|||:... :.|.....|::|.:.|...||..:|||::   :|| |.|...:|.|:.::.:|
 Worm     7 LLIGILVIWHLDNQVCGLSKEQQLEKQLMVKYNYKVRPVKSEATVTQ-VNVFLSIAHVEKVDEHE 70

  Fly    70 KNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNV-- 132
            :..::..::|  ..|.|..:||| |....:..|.:....:|:|.:.|:|:|.||....|...:
 Worm    71 QTALVHGHIW--ATWIDEYMQWD-AKKENVTKLTISAHSLWQPALALYNSARGNSWHLYMGAMPA 132

  Fly   133 LIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLA-LYNNKNF------ 190
            .:|.||:|.......:..:|..|.|.:|||||:|.:....|.:|.:||:|: .|..|.:
 Worm   133 TVYSTGKVWSTGTFSFYVTCQFDFTNWPFDQQSCPIVIADWVYNLNQVNLSDPYILKEYGKPSIR 197

  Fly   191 -----VDLSDYWKSGTWDIIEV--------PAYLNVYEGDSNHPTETDITFY-------IIIRRK 235
                 ::.||......|::::.        |      :|......|.:..:|       ||:||.
 Worm   198 LSYDPIEKSDKRHVAGWEVMDAWKKHCYWGP------KGCKEEQPEGEAEWYWSLLEFGIILRRH 256

  Fly   236 TLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIA 300
            ..:::::::.|....|.:.:|.|::...:....|:.::|:|.......|::| :||.|...|.|.
 Worm   257 LPYFSLSILFPMAGTSLILLLCFWIETHSICFFTIMLNIILQSYYGSSLLAK-MPPGSGRTPKIV 320

  Fly   301 KYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEM 365
            .......:::.|..::.|.......|.|:...:.:           .|..:..|::..:..:...
 Worm   321 HLYNMNLLLSAVQFVLIVFSEFLRLRLPKKFELDL-----------GFDIIGVPQRFGVDKLFTQ 374

  Fly   366 PGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGG----ELGLG 426
            .|:|.         .|.||   .|.:...::..|::|               ..||    .:|:|
 Worm   375 KGLSF---------DPQEL---FSNVYSTRTLEEILE---------------QGGGSSSTSVGIG 412

  Fly   427 DGCRRE----SESSDSILL-------SPEASKATEAVEFIAEHLRNEDLYI-QTREDWKYVAMVI 479
            :....:    .:||||.:|       .|::..|:.:....:|...||:..| :..|:.:.:.:.:
 Worm   413 NPLHEDITSFQKSSDSSVLIDIPMTSEPQSFSASTSELLSSEPSSNEETQISEEPEEERILDVQL 477

  Fly   480 DRLQLYIFFIVTTAGTVGILM 500
            ..::.|:|.:|.....:..|:
 Worm   478 RHIKRYVFCLVIFIHIIAFLL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	115/539 (21%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	62/240 (26%)
		Cys-loop	152..166	CDD:349833	8/13 (62%)
lgc-25	NP_510359.3	LGIC_ECD_cation	52..256	CDD:349790	53/213 (25%)
		Cys-loop	152..166	CDD:349790	8/13 (62%)