Protein Alignment nAChRbeta1 and lgc-21

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_510341.2
• Gene: lgc-21 / 181516
• WormBaseID: WBGene00007903
• Length: 462
• Species: Caenorhabditis elegans
• Alignment Length: 295
• Identity: 64/295 - (21%)
• Similarity: 117/295 - (39%)
• Gaps: 52/295 - (17%)

  Fly    51 QKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIV 115
            |.|.:.|....:|...:||..:.:..:.:|.|.|:|.:|.|::..:....::......:|.|.:.
 Worm   111 QPVTINFAQFTLQHFELNEHLKDISIHGYLELSWHDDRLMWNQDTWKKNKLVVHSFHHIWVPLLG 175

  Fly   116 LFN------NADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSC-TIDVTYFPFDQQTCIMKFG-- 171
            ..|      |.|. :|:|   .|.....|.|........::.| ..|...:|.|...|...|.
 Worm   176 SQNPENHLKNGDA-FEIR---KVETTNQGNVSAKVAFSLRTFCDDTDFENYPNDVYKCCFSFEPQ 236

  Fly   172 ------SWTFNGDQVSLALYNN-KNFVDLSDYW-KSGTWDIIEVPAYLNVYEGDSNHPTE-TDIT 227
                  .:|.:|    |.::.: |||.|..  | .|||     ||.       ..:.|:| ..:.
 Worm   237 QDREVIQFTSSG----LPIFTDPKNFRDYG--WGVSGT-----VPE-------SFDDPSEIAQLG 283

  Fly   228 FYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGE-KVTLGISI------LLSLVVFLLLV 285
            |.:.::|......:.|.:|.    |:...:|.||...|. |:.:.:.:      .::|::|...:
 Worm   284 FCLNLKRAHSSLKIELAIPL----FITTALFLLPPLFGSVKIQIYLKMFVMGLQFMTLLIFSTRI 344

  Fly   286 SKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVII 320
            :..|..|:.. |...::|....:.|.:||..::||
 Worm   345 APFLSSTAST-PKPMRFLEIALVFNLISITTSIII 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	64/295 (22%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	45/202 (22%)
		Cys-loop	152..166	CDD:349833	4/14 (29%)
lgc-21	NP_510341.2	LGIC_ECD	113..290	CDD:475126	43/198 (22%)