Protein Alignment nAChRbeta1 and acr-12

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_510262.1
• Gene: acr-12 / 181475
• WormBaseID: WBGene00000051
• Length: 573
• Species: Caenorhabditis elegans
• Alignment Length: 550
• Identity: 195/550 - (35%)
• Similarity: 304/550 - (55%)
• Gaps: 62/550 - (11%)

  Fly     7 SWLLCSILVLV----AFSLVSASED-EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLIN 66
            :|.|. :||.|    ||.:...::| |.:|..||...|||:.|||:|.:..:.|..|.:.:::|:
 Worm    13 NWALI-LLVAVGGTNAFKIKRTAKDLESQLYEDLLFDYNKVPRPVKNSSDILTVDVGASLIRIID 76

  Fly    67 VNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSN 131
            |:||||::.:|:||.:.|.|.:|.|....|||:..|.:|.|.:|.||:||:|||.|:.::...::
 Worm    77 VDEKNQVLTTNLWLEMKWNDAKLTWTPEKYGGLKTLHIPSDFIWTPDLVLYNNAAGDPDITILTD 141

  Fly   132 VLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALY----------- 185
            .|:...|.|.|.|||||:|.|.||||:||:|.|.|.||||:||:.|..|.|...
 Worm   142 ALVTFEGNVYWQPPAIYKSFCPIDVTWFPYDSQKCEMKFGTWTYTGRYVDLKQLPQEEVVTITKD 206

  Fly   186 -NNKNF----VDLSDYWKSGTWDIIEVPA--YLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNL 243
             |:..|    :|||.:::|..||::.:.:  :..:|..........|||:|..:||||||:|.||
 Worm   207 DNDVEFMQQGMDLSFFYRSAEWDLLSLTSERHSVLYASCCGPEKYVDITYYFGLRRKTLFFTCNL 271

  Fly   244 ILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFI 308
            |||..|||.|...||||   :..|:|..||||::|.||.|::..::||||||:|:..:||:.|.|
 Worm   272 ILPCFLISILTTFVFYL---SDHKITFSISILVTLTVFFLVLIDLMPPTSLVIPMFGRYLITTMI 333

  Fly   309 MNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAH 373
            :..:|.:|:||.:|:.||....|:|..:||::||.:||..|.|.||.|..:  ..:.|.::..:.
 Worm   334 LVALSTVVSVITVNFRFRSGSAHKMSPWIRAVFLKFLPKILLMSRPEKGEV--TKQPPLVNAASL 396

  Fly   374 PHPSYGSPAELPKH-----------ISAIGGKQSKMEVMELS-DLHHPN-------------CKI 413
            ...:|.:.|:....           :.::.||.|...|:..: |:...|             |..
 Worm   397 VGSNYATAAKAANEYRNKAKGKNNDLMSLRGKPSSQAVLNNTFDMRMRNNDSTVENRLKPYLCAQ 461

  Fly   414 NRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMV 478
            |   |:...:......|::|:|.|.::.    ......|.|||||.|:.:|..:..:||.:||||
 Worm   462 N---NNAPTVAFRKTKRQKSKSVDDVVF----MNLLNQVRFIAEHFRHNELEGEISDDWTFVAMV 519

  Fly   479 IDRLQLYIFFIVTTAGTVGILMDAPHIFEY 508
            :|||.| |.|.|...|||.|::::|.:::|
 Worm   520 LDRLFL-IIFSVLNVGTVFIILESPSLYDY 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	193/539 (36%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	86/227 (38%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
acr-12	NP_510262.1	LIC	14..539	CDD:455710	192/538 (36%)
		LGIC_ECD	40..266	CDD:475126	86/225 (38%)