Protein Alignment nAChRbeta1 and acr-8

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001361818.1
• Gene: acr-8 / 181246
• WormBaseID: WBGene00000047
• Length: 540
• Species: Caenorhabditis elegans
• Alignment Length: 515
• Identity: 185/515 - (35%)
• Similarity: 285/515 - (55%)
• Gaps: 71/515 - (13%)

  Fly    19 FSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLV 83
            |..|:.:...:::..||...|||.:||::|.::.|.|:||.:.:::|:|:|.||::.:|:||.:.
 Worm    16 FFYVNPNRYADQMYEDLLYYYNKNVRPIKNASESVKVKFGSSLIRIIDVDEVNQVLTTNLWLEMQ 80

  Fly    84 WYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIY 148
            |:||:|.||...:|.|..|.:|.|::|.|||:|:|||||...:...|:.::|..|.|:|.||:||
 Worm    81 WFDYRLMWDPGRWGKIRKLHVPVDQIWIPDILLYNNADGEPHITIMSDAIVYYNGLVVWKPPSIY 145

  Fly   149 QSSCTIDVTYFPFDQQTCIMKFGSWTFNG---DQVSLALYN----NK-----------NFVDLSD 195
            :|.|:||:.|||:|.|||.||||.||:||   |...|....    ||           ..:|||.
 Worm   146 KSFCSIDIEYFPYDTQTCWMKFGGWTYNGFLLDVRQLPTTGCEVVNKADDEGEFQFLGRGMDLSG 210

  Fly   196 YWKSGTWDIIEVPA--YLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVF 258
            |:.|..||::|:.:  :..:|.|........||||.|.|||||||||:||::|..:.:.|..:||
 Worm   211 YYPSLEWDLMELNSARHEKIYAGCCGQDFYIDITFKIEIRRKTLFYTINLMIPCTMFAILTSIVF 275

  Fly   259 YLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINW 323
            |:| ....|:|..||||::|.||.|::..::||||||:|||.||||||..:.::||:::||.:|:
 Worm   276 YVP-PIEHKMTFSISILVTLTVFYLILIDLVPPTSLVIPLIGKYLLFTMFLVSISIMLSVISLNF 339

  Fly   324 NFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHI 388
            ..|...:..||.:::.:|:|.||.::.:|...:                      ...::....|
 Worm   340 YRRDGSSFPMPHWMKVVFIHTLPRYICIKTAEE----------------------DDGSDRGSSI 382

  Fly   389 SAIGGKQSKMEVMELSDLHHPN---CKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATE 450
            |.||         ...|...|:   ..:|.:..:|          |.||.....:.........:
 Worm   383 SDIG---------PFMDSRRPSPFFITVNERQLNG----------RLSELKKKGMHPDLIRNMIQ 428

  Fly   451 AVEFIAEH---LRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFE 507
            .||||||:   |:.||   :..|||.|||.||||:.|.||.|:...||..||:::|.:|:
 Worm   429 NVEFIAEYFNSLKKED---KVSEDWSYVANVIDRIFLIIFSIMNVVGTWVILLNSPALFD 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	182/506 (36%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	91/228 (40%)
		Cys-loop	152..166	CDD:349833	8/13 (62%)
acr-8	NP_001361818.1	LGIC_ECD	24..255	CDD:475126	93/230 (40%)
		Neur_chan_memb	260..476	CDD:460753	81/260 (31%)