Protein Alignment nAChRbeta1 and lev-1

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001255705.1
• Gene: lev-1 / 178269
• WormBaseID: WBGene00002974
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 529
• Identity: 248/529 - (46%)
• Similarity: 332/529 - (62%)
• Gaps: 65/529 - (12%)

  Fly     7 SWLLCSILVLVAFSL--VSASED---EERLVRDLFRGYNKLIRPVQNMTQ-KVGVRFGLAFVQLI 65
            :||  ..||.:|.||  .|..||   |:||:.|||||||.|::||:|.:: .:.|:.|:..|.||
 Worm    14 TWL--GFLVFLAVSLRNHSTCEDIDAEDRLMVDLFRGYNSLVQPVRNRSELPMIVKIGMQLVLLI 76

  Fly    66 NVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKS 130
            ||:||.|:|.:||||.:.|.|:||:||..||..|..:|:.|:|||.|||||||||||||||.:..
 Worm    77 NVDEKEQVMHTNVWLTMKWDDFQLKWDPRDYANITQIRVAPEKVWLPDIVLFNNADGNYEVSFMC 141

  Fly   131 NVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSD 195
            ||||..||.|||||||||:|||.|||.:||||.|.|.:.|||||:|.|::.|....:.. ||.|:
 Worm   142 NVLILSTGTVLWVPPAIYKSSCIIDVEFFPFDDQLCSLTFGSWTYNRDEIKLDFLTSDR-VDFSE 205

  Fly   196 YWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYL 260
            |..|..||:::.||.|.        ...:.|.|.|.||||||||||.|||||||::||.|.||||
 Worm   206 YSTSSIWDMMDGPAVLT--------SDRSRIEFQIRIRRKTLFYTVVLILPTVLMAFLNVTVFYL 262

  Fly   261 PAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNF 325
            |..:|||:.|.:::|||:|||||||||||||||..:||:|||||.||::|.::|:||.||.|..|
 Worm   263 PTASGEKMGLTMNVLLSIVVFLLLVSKILPPTSSSIPLVAKYLLLTFVLNIITIMVTTIICNIYF 327

  Fly   326 RGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRL-----RWMMEMPGMSMPAHPHPSYGSPAELP 385
            |.|.|||:|.::|.:||..||..:.|:||.:..:     |.::| .|.|:..:|..|
 Worm   328 RSPITHRLPPWVRKVFLDILPLLMCMQRPHRKNVIQRSHRRLLE-TGPSVEENPMRS-------- 383

  Fly   386 KHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSI--LLSPEASKA 448
                   |:            |||.|:....         .|.|||....||.:  .|||||.:|
 Worm   384 -------GE------------HHPLCRHTHN---------QDSCRRVRIQSDELDDELSPEAQRA 420

  Fly   449 TEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQD- 512
            .:|:|||.|:.|:|::..|.|:|||::|.|:||..||.||..|..||:||:..||.:||..|::
 Worm   421 IDAIEFITENRRDEEITKQFRDDWKFIASVVDRFLLYGFFGATVGGTIGIIFTAPSVFETFDENA 485

  Fly   513 ---RIIEIY 518
               ::.::|
 Worm   486 TLVKLKQLY 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	242/504 (48%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	110/212 (52%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
lev-1	NP_001255705.1	LIC	15..474	CDD:455710	242/506 (48%)
		LGIC_ECD_nAChR_proto_beta-like	37..238	CDD:349833	109/209 (52%)
		Cys-loop	163..177	CDD:349833	9/13 (69%)