Protein Alignment nAChRbeta1 and cup-4

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_498710.2
• Gene: cup-4 / 176104
• WormBaseID: WBGene00000845
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 374
• Identity: 80/374 - (21%)
• Similarity: 151/374 - (40%)
• Gaps: 80/374 - (21%)

  Fly    23 SASEDEERLVRDLFRGYNKLIRPVQNMT--QKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWY 85
            |.||.:..|.:.:|||||...||::|.:  ..|.|.:.:..|. ||..|:...:..::::|  |:
 Worm    43 SYSEHQSALEQKIFRGYNPKNRPMKNASFPTIVDVHWHIIHVS-INQREQTMTVHGHIYMR--WF 104

  Fly    86 DYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADG---NYEVRYKSNVLIYPTG----EVLWV 143
            |..|.||..|:..|...|:...:||:|.|.:.|:|.|   .::....::|:|...|    :|...
 Worm   105 DEFLVWDPKDFNNIQYARVKKWQVWQPKIKVSNSASGLGSAFDFSTSAHVIIQMMGKDRAKVEMY 169

  Fly   144 PPAIYQSSCTIDVTYFPFDQQTC-----------------------IMKFGSW----------TF 175
            |....:..|..|.|.:|:|...|                       .:.|| |          .|
 Worm   170 PTFSIKVGCAFDFTDYPYDLNKCAINLFSTSTMADVQLQNLYAIPPTLSFG-WEEQKMKRIISDF 233

  Fly   176 NGDQVSLA--LYNNKNFVD---LSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRK 235
            ....||.:  .|.|.|...   ::.:....||.::.|                 .::|   :|..
 Worm   234 KIQNVSSSALYYTNGNITSSAPITGFDLGSTWSMLAV-----------------TVSF---VRHS 278

  Fly   236 TLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIA 300
            .||... ::.|.::::.|..:.|::.:.:...:.:.:...:.|:....||.| ||.:...:|...
 Worm   279 PLFEAA-VVTPCIVVASLISMTFFIDSLSSTFLLMMLHFYVQLIFLHDLVEK-LPLSVSEIPFCI 341

  Fly   301 KYLLFTFIMNTVS-ILVTVIIINWNFRGPRTHRMPMYIRSIFL--HYLP 346
            |.:......|.:: :|.:.::....::.|    :|..:..||:  .|:|
 Worm   342 KLIGILMYTNGLTLVLHSSLLCGSYYKCP----VPQQLNKIFVIEEYIP 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	80/374 (21%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	56/255 (22%)
		Cys-loop	152..166	CDD:349833	5/13 (38%)
cup-4	NP_498710.2	LGIC_ECD_cation	73..246	CDD:349790	39/176 (22%)
		Cys-loop	178..192	CDD:349790	5/13 (38%)