Protein Alignment nAChRbeta1 and lgc-20

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_496423.1
• Gene: lgc-20 / 174733
• WormBaseID: WBGene00007191
• Length: 454
• Species: Caenorhabditis elegans
• Alignment Length: 323
• Identity: 70/323 - (21%)
• Similarity: 136/323 - (42%)
• Gaps: 61/323 - (18%)

  Fly    46 VQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVW--LRLVWYDYQLQWDE----ADYGGIGVLRL 104
            ::|:..|        :|:|:    |....:.||:  :.|.|.|.:::||:    .:|..:.:..
 Worm    72 IENVLVK--------YVELV----KGSSYQFNVFGDIYLNWKDERMKWDKKGEFENYEHLYIFN- 123

  Fly   105 PPDKVWKPDIV---LFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTC 166
             ...:|.|.::   |.:....:|.|   .:|.||..|.:.......|.:|||:|...||.:..:|
 Worm   124 -SSAIWTPHVIDHTLCSEGGCSYSV---DDVDIYDDGTIYARIQFKYLASCTVDYRKFPEEDDSC 184

  Fly   167 IMKFGSWTFNGDQVSLAL------------YNNKNF---VDLSD-YWKSGTWDIIEVPAYLNVYE 215
            .:.|.::..|.:|.:|.|            |..|.:   ..||| ..:...|.::|.....:...
 Worm   185 CIFFTAFEPNVEQTTLVLEGKEKEKMNRPVYAQKIYEKEKQLSDIVQEHSPWVVVEKTMSTSNLG 249

  Fly   216 GDSNHPTETDITFYIIIRRKTLFYTVN--LILPTVLISFLCVLVFYLPAEAGEKVTLGI-SILLS 277
            |     .::.....:.:|.:....||.  |:.|..|.::: :|...|..:...::.:.: |:.:.
 Worm   250 G-----LKSLQVMQVCVRAEKQMSTVRVALLFPVTLATYV-MLASPLFGDLRTQIYVKLFSLHIQ 308

  Fly   278 LVVFLLLVSKILPPTSL--VLPLIAKYLLFTFIMNTVSILVTVII-----INWNFRGPRTHRM 333
            .:.||.|.: |.|....  |.|.|..:....|.::.:|||||:::     :..|.  |.:||:
 Worm   309 TLCFLYLCT-ITPLNGFLGVRPRIYIFYELIFTISFMSILVTLVVMALSRVKRNV--PPSHRL 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	70/323 (22%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	44/214 (21%)
		Cys-loop	152..166	CDD:349833	5/13 (38%)
lgc-20	NP_496423.1	LGIC_ECD	68..>206	CDD:475126	35/150 (23%)