Protein Alignment nAChRbeta1 and unc-63

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_491533.2
• Gene: unc-63 / 172150
• WormBaseID: WBGene00006797
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 527
• Identity: 220/527 - (41%)
• Similarity: 302/527 - (57%)
• Gaps: 76/527 - (14%)

  Fly    16 LVAFSLVS----ASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKS 76
            ::.|.|:|    |:.|..||..||...||||:|||....:.:.|.|.|...||::|:||||||.:
 Worm    11 ILIFLLLSPPTHANRDANRLFEDLIADYNKLVRPVSENGETLVVTFKLKLSQLLDVHEKNQIMTT 75

  Fly    77 NVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVL 141
            ||||:..|.||:|:||..:|||:.||.:|.|.:|.||:||:|||||||:|...:...:...|.|.
 Worm    76 NVWLQHSWMDYKLRWDPVEYGGVEVLYVPSDTIWLPDVVLYNNADGNYQVTIMTKAKLTYNGTVE 140

  Fly   142 WVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNF---------------- 190
            |.|||||:|.|.|||.:||||:|.|.|||||||:.|.:|.|. :.:|:.
 Worm   141 WAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVDLQ-HRDKHLEKEIEEDVEGVDGPTK 204

  Fly   191 ---------VDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILP 246
                     :|||||:.|..|||:.||...:............|||:.|.:||||||||||||.|
 Worm   205 EIVWVVDRGIDLSDYYPSVEWDILNVPGKRHSKRYPCCESPFIDITYEIHLRRKTLFYTVNLIFP 269

  Fly   247 TVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNT 311
            :|.||||..||||||::.|||::|.||||:||.||.||:.:|:|.||||:|||.||||||.::.|
 Worm   270 SVGISFLTALVFYLPSDGGEKISLCISILISLTVFFLLLVEIIPSTSLVIPLIGKYLLFTMVLVT 334

  Fly   312 VSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAH--- 373
            :|::|||:.:|.::|.|.||.||.:::.:|:.:||.:|.|.||:.              |.|
 Worm   335 LSVVVTVVTLNVHYRSPTTHTMPKWMKRLFVDFLPKYLLMTRPQP--------------PGHHSK 385

  Fly   374 PHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDS 438
            |:..:.|.|.    ..:||                    :|..:....|| |..|.....|.|..
 Worm   386 PNRKFDSRAS----TFSIG--------------------VNHVLGQNSEL-LSPGLNSNREESSF 425

  Fly   439 IL---LSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            .|   .||..| |.|:|.:||:||:||:...|..|||||:::|:||:.|..|......|||.|:.
 Worm   426 TLPRDNSPVRS-AVESVAYIADHLKNEEDDKQVIEDWKYISVVMDRIFLITFTFACAFGTVVIIA 489

  Fly   501 DAPHIFE 507
            .||.|::
 Worm   490 RAPSIYD 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	217/518 (42%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	101/233 (43%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
unc-63	NP_491533.2	LIC	6..487	CDD:455710	216/516 (42%)
		LGIC_ECD_nAChR_proto_alpha-like	26..261	CDD:349832	103/235 (44%)
		Cys-loop	151..165	CDD:349832	9/13 (69%)