Protein Alignment nAChRbeta1 and unc-38

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_491472.1
• Gene: unc-38 / 172105
• WormBaseID: WBGene00006774
• Length: 511
• Species: Caenorhabditis elegans
• Alignment Length: 531
• Identity: 212/531 - (39%)
• Similarity: 305/531 - (57%)
• Gaps: 76/531 - (14%)

  Fly     8 WL-LCSILVLVAF-SLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEK 70
            || |..:|..::| .|...:||.:||..||...||:..||..:..:.:.::..|...|:|:|:|.
 Worm     5 WLFLLLLLFCISFIKLTEGNEDAKRLYDDLMVNYNRHRRPSTSPNKPLTIKLKLRLSQIIDVHEI 69

  Fly    71 NQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIY 135
            :|||..:|||:..|.|.:|.||..:|||:.||.:|.:.:|.|||||:||||.||.:...:...::
 Worm    70 DQIMTCSVWLKQTWIDRKLSWDPVNYGGVNVLYVPYEMIWVPDIVLYNNADSNYNITISTKATLH 134

  Fly   136 PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL------YNN------- 187
            .||||.|.||||::|.|.|||.:||||:|.|.:|||||||:.:.:|:.|      |..
 Worm   135 YTGEVTWEPPAIFKSMCQIDVRWFPFDEQQCHLKFGSWTFSENLLSVELNEPSLRYEEEIDEKGI 199

  Fly   188 -------KNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPT------ETDITFYIIIRRKTLFY 239
                   ::.:|||||:.|..|||:...|....    .|:|:      ..|:|:|:.:|||.|||
 Worm   200 IDNVTVAEDGIDLSDYYPSVEWDIMSRVAKRRA----KNYPSCCPQSAYIDVTYYLQLRRKPLFY 260

  Fly   240 TVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLL 304
            ||||:.|.|.||||.:||||||:::||||||.||||::|.:|.||:::|:|.||:.||||.||||
 Worm   261 TVNLVFPCVGISFLTILVFYLPSDSGEKVTLCISILVALTIFFLLLTEIIPATSITLPLIGKYLL 325

  Fly   305 FTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMS 369
            ||.:|.|:|::||||.:|.:||.|.||.||.:::.:||.:||..|||:||
 Worm   326 FTMVMVTLSVVVTVISLNLHFRTPTTHLMPNWVKKVFLKWLPKLLFMRRP--------------- 375

  Fly   370 MPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHP-NCKINRKVNSGGELGLGDGCRRES 433
                                 |...:.|.:     |...| :.||...|::.....:|:..|..:
 Worm   376 ---------------------IDDYEEKFD-----DKKKPKDGKIALSVHAHRVSNVGNNIRNAT 414

  Fly   434 --ESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTV 496
              ::...:..||...||.|.:.||||.|:.:|...:..|||||||||:|||.|.||.|....|||
 Worm   415 IDDTIQKMYYSPPVVKAFENICFIAELLKKKDRDDKIDEDWKYVAMVLDRLFLLIFSIACFVGTV 479

  Fly   497 GILMDAPHIFE 507
            .||:.||.:::
 Worm   480 IILLRAPTLYD 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	209/522 (40%)
		Neur_chan_LBD	28..236	CDD:280998	89/233 (38%)
		Neur_chan_memb	243..498	CDD:280999	104/257 (40%)
unc-38	NP_491472.1	Neur_chan_LBD	27..257	CDD:280998	89/233 (38%)
		LIC	29..483	CDD:273305	201/498 (40%)
		Neur_chan_memb	264..481	CDD:280999	104/257 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820