Protein Alignment nAChRbeta1 and Chrnb3

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_598281.1
• Gene: Chrnb3 / 171131
• RGDID: 621544
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 499
• Identity: 194/499 - (38%)
• Similarity: 289/499 - (57%)
• Gaps: 64/499 - (12%)

  Fly     7 SWLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            ||    :.:.....|.|.:|.|:.|:|.||:||.|.:|||.|.:..:.|.|||...||::|:|||
  Rat    18 SW----VTLTATAGLSSVAEHEDALLRHLFQGYQKWVRPVLNSSDIIKVYFGLKISQLVDVDEKN 78

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136
            |:|.:||||:..|.|.:|:|:..:||||..:::|.:.:|.||||||.||||.:|....:..::..
  Rat    79 QLMTTNVWLKQEWTDQKLRWNPEEYGGINSIKVPSESLWLPDIVLFENADGRFEGSLMTKAIVKS 143

  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201
            :|.|.|.|||.|:||||:|||:||||:|.|.|||||||::|..|.|.|.|..  ||..|::.:|.
  Rat   144 SGTVSWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINEN--VDRKDFFDNGE 206

  Fly   202 WDIIEVPAYL-NVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG 265
            |:|:...... |..||..::|.   :|:..::||..||||:.||:|.:.:|||.|||||||::.|
  Rat   207 WEILNAKGMKGNRREGFYSYPF---VTYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG 268

  Fly   266 EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT 330
            ||::|..|:|:||.||||::.:|:|.:|.|:|||.:||||..|..|:||:|||.:||.:.|...|
  Rat   269 EKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSST 333

  Fly   331 -HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGK 394
             |.|..:::.:||..||.:|.||.|          |...|.|                    .||
  Rat   334 YHPMAPWVKRLFLQRLPRWLCMKDP----------MDRFSFP--------------------DGK 368

  Fly   395 QSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSD-SILLSPEASKATEAVEFIAEH 458
            :|...|.                      |...|.|:::.:|| ..:|.....||:|::.:|:.|
  Rat   369 ESDTAVR----------------------GKVSGKRKQTPASDGERVLVAFLEKASESIRYISRH 411

  Fly   459 LRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502
            ::.|....|..:|||:||.|:||:.|::|.|.:..|::.|.:.|
  Rat   412 VKKEHFISQVVQDWKFVAQVLDRIFLWLFLIASVLGSILIFIPA 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	192/494 (39%)
		Neur_chan_LBD	28..236	CDD:280998	94/208 (45%)
		Neur_chan_memb	243..498	CDD:280999	89/256 (35%)
Chrnb3	NP_598281.1	LIC	29..455	CDD:273305	190/482 (39%)
		Neur_chan_LBD	35..239	CDD:280998	94/208 (45%)
		Neur_chan_memb	246..452	CDD:280999	89/257 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820