Protein Alignment nAChRbeta1 and Chrna2

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_596911.1
• Gene: Chrna2 / 170945
• RGDID: 621533
• Length: 511
• Species: Rattus norvegicus
• Alignment Length: 514
• Identity: 233/514 - (45%)
• Similarity: 319/514 - (62%)
• Gaps: 32/514 - (6%)

  Fly     3 SSCKSW----LLCSILV-LVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFV 62
            |:.:.|    |.|.:|| .|.....|.:..|:||.:.||.|||:..|||.|.:..|.|||||:..
  Rat     6 SALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIA 70

  Fly    63 QLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVR 127
            |||:|:||||:|.:||||:..|.||:|:||.|::|.:..||:|.:.:|.|||||:|||||.:.|.
  Rat    71 QLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNADGEFAVT 135

  Fly   128 YKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVD 192
            :.:...::.||.|.|||||||:|||:||||:||||||.|.|||||||:  |:..:.|...:..||
  Rat   136 HMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTY--DKAKIDLEQMERTVD 198

  Fly   193 LSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLV 257
            |.|||:||.|.||......|..:.|.......|:|:|.:|||..||||:|||:|.:|||.|.|||
  Rat   199 LKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLV 263

  Fly   258 FYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIIN 322
            ||||:|.|||:||.||:||||.|||||:::|:|.||||:|||.:|||||.|..|:||::||.::|
  Rat   264 FYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN 328

  Fly   323 WNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHP----HPSYGSPAE 383
            .:.|.|.||.||.::|...|..:|.:|.|.||          :|.|.:...|    .|||   ..
  Rat   329 VHHRSPSTHNMPNWVRVALLGRVPRWLMMNRP----------LPPMELHGSPDLKLSPSY---HW 380

  Fly   384 LPKHISAIGGKQSKMEVMELSDLH------HPNCKINRKVNSGG-ELGLGDGCRRESESSDSILL 441
            |..::.| |.::...|..|..|.:      .|:..:......|| .|...:...:....:..|||
  Rat   381 LETNMDA-GEREETEEEEEEEDENICVCAGLPDSSMGVLYGHGGLHLRAMEPETKTPSQASEILL 444

  Fly   442 SPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            ||:..||.|.|.:||:.||:||.....:|||||||||:||:.|::|.||...||:|:.:
  Rat   445 SPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	232/507 (46%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	106/208 (51%)
		Cys-loop	152..166	CDD:349833	11/13 (85%)
Chrna2	NP_596911.1	LIC	35..504	CDD:455710	225/485 (46%)
		LGIC_ECD_nAChR_A2	36..242	CDD:349816	106/207 (51%)
		Cys-loop	160..174	CDD:349816	11/13 (85%)