DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta1 and HTR3C

DIOPT Version :10

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_570126.2 Gene:HTR3C / 170572 HGNCID:24003 Length:447 Species:Homo sapiens


Alignment Length:441 Identity:111/441 - (25%)
Similarity:190/441 - (43%) Gaps:78/441 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 KSWLLCSILVLV------AFSLVSASEDEERLVRDLFRGY--NKLIRPVQNMTQKVGVRFGLAFV 62
            :|.|||..:.|:      ||::..:..|:..:...:|:..  .|..||..|.:....|.......
Human     9 QSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLS 73

  Fly    63 QLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVR 127
            .::.|:.:.|::.|.:|:.|||.:..:.|:..:..||..|.:..:.:|.|||.:..:.|.:   :
Human    74 AILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVD---Q 135

  Fly   128 YKSNVLIY--PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNF 190
            ..|.:..|  ..|.:.:..|....|.|.:|:.|||||||.|...|.|:.:..|.:.|.:  :|..
Human   136 TPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGM--DKEV 198

  Fly   191 VDLSDYWK-----SGTWDIIEVPAYL-------NVYEGDSNHPTETDITFYIIIRRKTLFYTVNL 243
            .:::|..:     .|.|:::.:....       |:|:         .|.||:.|||:...|.:||
Human   199 WEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYD---------QIMFYVAIRRRPSLYIINL 254

  Fly   244 ILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFI 308
            ::|:..:..:..|.||||||:..:....|::||...||||:::.:||.:.  .|||:.|......
Human   255 LVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASG--TPLISVYFALCLS 317

  Fly   309 MNTVSILVTVIIIN-WNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPA 372
            :..||:|.||.|.. .:....:...||.::.|:.||                   ...||...|.
Human   318 LMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLH-------------------CTSPGRCCPT 363

  Fly   373 HPH-------------PSYGSPAEL------PKHISAIGGK-QSKMEVMEL 403
            .|.             |....|.||      |:.....||. .:|.::|||
Human   364 APQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMEL 414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:455710 110/439 (25%)
LGIC_ECD_nAChR_proto_beta-like 27..236 CDD:349833 54/224 (24%)
Cys-loop 152..166 CDD:349833 9/13 (69%)
HTR3CNP_570126.2 LGIC_ECD_5-HT3C_E 31..246 CDD:349814 53/228 (23%)
Cys-loop 162..176 CDD:349814 9/13 (69%)
LGIC_TM_5-HT3 248..446 CDD:349865 50/188 (27%)
TM1 helix 248..272 CDD:349865 7/23 (30%)
TM2 helix 280..301 CDD:349865 7/20 (35%)
TM3 helix 310..332 CDD:349865 7/21 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..405 7/24 (29%)
HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000250|UniProtKB:P46098 401..423 6/14 (43%)
TM4 helix 421..443 CDD:349865
Blue background indicates that the domain is not in the aligned region.

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