Protein Alignment nAChRbeta1 and LOC1275447

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_061509055.1
• Gene: LOC1275447 / 1275447
• VectorBaseID: AGAMI1_001711
• Length: 551
• Species: Anopheles gambiae
• Alignment Length: 529
• Identity: 201/529 - (37%)
• Similarity: 304/529 - (57%)
• Gaps: 49/529 - (9%)

  Fly     8 WLLCSILVLVAFS--LVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEK 70
            |::  :|:|:|.|  |..|..:|:||:.||...||.|.|||.|.:..:.:.|||..:|:|:|:||
Mosquito    38 WII--VLMLIANSSILCMAGYNEKRLLHDLLDSYNILERPVVNESDPLQLSFGLTLMQIIDVDEK 100

  Fly    71 NQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIY 135
            ||::.:|:||:|.|.|..|:|:.::|||:..||:||.::||||::::|:||..::..|.:||::.
Mosquito   101 NQLLVTNIWLKLEWNDMNLRWNTSEYGGVRDLRIPPHRIWKPDVLMYNSADEGFDGTYPTNVVVR 165

  Fly   136 PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSG 200
            ..|..|:|||.|::|:|.||:|:||||.|.|.|||||||::|.|:.|.|.:... .|:|.:..:|
Mosquito   166 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAG-GDVSSFVTNG 229

  Fly   201 TWDIIEVPAYLN-VYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA 264
            .||::.||...| :|......| ..||||.|||||:||:|..|||:|.|||:.:.:|.|.||.::
Mosquito   230 EWDLLGVPGKRNEIYYNCCPEP-YIDITFAIIIRRRTLYYFFNLIVPCVLIASMALLGFTLPPDS 293

  Fly   265 GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPR 329
            |||::||::|||||.|||.:|::.:|.||..:||:..|......|...|::.|::|:|::.|...
Mosquito   294 GEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNAD 358

  Fly   330 THRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAI--- 391
            ||.|..::|.|||::||..|.|.||.:          .:||...|.|:..| :|...||..:
Mosquito   359 THEMSDWVRVIFLYWLPCILRMSRPGR----------DLSMEYPPTPTSDS-SERKAHIQDVELK 412

  Fly   392 --GGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSP----------- 443
              ..|.....|:::.|....||   |.:..||.|.......|...|||...:.|
Mosquito   413 ERSSKSLLANVLDIDDDFRHNC---RPLTPGGTLPHNPTYFRTVYSSDDGSIGPIGTNRMPDAIA 474

  Fly   444 ------------EASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTV 496
                        |.:...:.:.||.:.:|.||......:|||:.|||:|||.|.||...|...|:
Mosquito   475 PPHTCFTSSADYELALILKEIRFITDQIRKEDEESDIAKDWKFAAMVVDRLCLIIFTFFTIVATI 539

  Fly   497 GILMDAPHI 505
            .:|..||||
Mosquito   540 AVLFSAPHI 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	196/522 (38%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	94/209 (45%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
LOC1275447	XP_061509055.1	None