Protein Alignment nAChRbeta1 and LOC1271929

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_061514509.1
• Gene: LOC1271929 / 1271929
• VectorBaseID: AGAMI1_007824
• Length: 710
• Species: Anopheles gambiae
• Alignment Length: 674
• Identity: 250/674 - (37%)
• Similarity: 340/674 - (50%)
• Gaps: 181/674 - (26%)

  Fly    15 VLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVW 79
            :....|:...:.|.:||..||...||||:|||.|:|..:.|:..|...|||:||.|||||.:|:|
Mosquito    11 IFAVVSVCGGNPDAKRLYDDLLSNYNKLVRPVVNVTDALTVKIKLKLSQLIDVNLKNQIMTTNLW 75

  Fly    80 LRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVP 144
            :...||||:|:|:..:|||:.:|.:|.|.:|:|||||:||||||:||...:...:..||.|.|.|
Mosquito    76 VEQTWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRP 140

  Fly   145 PAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN-------FVDLSDYWKSGTW 202
            ||||:|||.|||.|||||:|||:|||||||::|.||.|...:..|       .||||:::.|..|
Mosquito   141 PAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDEMNETNVVEVGVDLSEFYTSVEW 205

  Fly   203 DIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEK 267
            ||:||||..|............||||.|.:||||||||||||:|.:.||||.:||||||:::|||
Mosquito   206 DILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEK 270

  Fly   268 VTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHR 332
            |:|.|||||||.||.||:::|:||||||:||:.|::|||.|::|.||.||||::|.:||.|:||.
Mosquito   271 VSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVIVLNIHFRSPQTHT 335

  Fly   333 MPMYIRSIFLHYLPAFLFMKRPRKTRL--------RWMM---EMPGMSMPAHP-----HPS---- 377
            |..::|:||:::||..|.|:||....|        |:|:   ...|..:|..|     .||
Mosquito   336 MAPWVRTIFINHLPKLLVMRRPIYQPLHHFSAASQRFMLRSCNSLGDHIPPLPPTIAFDPSVLLD 400

  Fly   378 ---------------YGSPAELPKHISAIGGKQSK----------MEVMELSDL------HH--- 408
                           :|||..|..|.|..||:...          |::|:...|      ||
Mosquito   401 HHLLDSSESLNTCRLHGSPTHLHNHRSGGGGRHHHHHHHSALVRGMDLMDDMPLPYHDHNHHNSP 465

  Fly   409 ----------------PN-CKINRKVNS-----GGEL--------------------GLGD---- 427
                            || ...|...||     ||.|                    |.|:
Mosquito   466 MSPINFNLLSAASTAVPNPAATNATANSTTTGAGGLLDPNSNFHKSLAAANTNDSKTGTGNLLLK 530

  Fly   428 --GCRRESESSDSILLS------------------------------------------------ 442
              |........:|:.|:
Mosquito   531 TAGATGHLSCCNSLFLNDLQQAAAVTTGATTADLLLGDNGVAVPLNNNLPTNVLPSGMIINTTDT 595

  Fly   443 ------------------------PEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQ 483
                                    ||.:||.:.|.:||:|.|.|:...:.:|||||||||:|||.
Mosquito   596 GTTVPAGGGKGDKTGPNRNRWLECPELTKAMDGVTYIADHTRKEEESSRVKEDWKYVAMVLDRLF 660

  Fly   484 LYIFFIVTTAGTVGILMDAPHIFE 507
            |:||.|....||.||::.||.:::
Mosquito   661 LWIFTIAVVFGTAGIILQAPTLYD 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	248/665 (37%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	109/215 (51%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
LOC1271929	XP_061514509.1	None