Protein Alignment nAChRbeta1 and nAChRbeta1

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_309158.3
• Gene: nAChRbeta1 / 1270461
• VectorBaseID: AGAMI1_011382
• Length: 519
• Species: Anopheles gambiae
• Alignment Length: 520
• Identity: 479/520 - (92%)
• Similarity: 494/520 - (95%)
• Gaps: 9/520 - (1%)

  Fly     7 SWLLCSILVLVA--FSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNE 69
            |.|:.|:|:.:.  ..:.|.|||||||||||||||||||||||||||||.|||||||||||||||
Mosquito     4 SVLILSVLLALQQYLGMGSCSEDEERLVRDLFRGYNKLIRPVQNMTQKVDVRFGLAFVQLINVNE 68

  Fly    70 KNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLI 134
            |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito    69 KNQIMKSNVWLRLVWSDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLI 133

  Fly   135 YPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKS 199
            ||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   134 YPNGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKS 198

  Fly   200 GTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA 264
            |||||||||||||||||   :||||||||||||||||||||||||||||||||||||||||||||
Mosquito   199 GTWDIIEVPAYLNVYEG---NPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA 260

  Fly   265 GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPR 329
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   261 GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPR 325

  Fly   330 THRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMP--AHPHPSYGSPAELPKHISAIG 392
            ||||||:|||:|||||||.|.|||||||||||||||||||:|  .|.|||||||||:||||||:|
Mosquito   326 THRMPMWIRSVFLHYLPAMLLMKRPRKTRLRWMMEMPGMSVPPQPHTHPSYGSPAEIPKHISALG 390

  Fly   393 GKQSKMEVMELSDLHHPNCKINRKVNSGGELGLG-DGCRRESESSDSILLSPEASKATEAVEFIA 456
            .|||||||||||||||||||:|||:|| |:||:| |.||||||||||||||||||||||||||||
Mosquito   391 AKQSKMEVMELSDLHHPNCKMNRKLNS-GDLGIGADSCRRESESSDSILLSPEASKATEAVEFIA 454

  Fly   457 EHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEIYRGK 521
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   455 EHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEIYRGK 519

  Fly   522  521
            Mosquito   520  519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	455/496 (92%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	201/208 (97%)
		Cys-loop	152..166	CDD:349833	13/13 (100%)
nAChRbeta1	XP_309158.3	LIC	6..498	CDD:455710	456/496 (92%)
		LGIC_ECD_nAChR_proto_beta-like	26..232	CDD:349833	198/205 (97%)
		Cys-loop	151..165	CDD:349833	13/13 (100%)