Protein Alignment nAChRbeta1 and LOC1270457

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_061509986.1
• Gene: LOC1270457 / 1270457
• VectorBaseID: AGAMI1_000573
• Length: 658
• Species: Anopheles gambiae
• Alignment Length: 536
• Identity: 193/536 - (36%)
• Similarity: 301/536 - (56%)
• Gaps: 57/536 - (10%)

  Fly     9 LLCSILVLVA-FSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQ 72
            ||..||.:.| ..::.|...|:||:..|...||.|.|||.|.:..:.:.|||..:|:|:|:||||
Mosquito   136 LLPLILGIAAMLPVIDAGYHEKRLLHHLLDNYNVLERPVVNESDPLQLSFGLTLMQIIDVDEKNQ 200

  Fly    73 IMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPT 137
            ::.:|:||:|.|.|..::|:.::|||:..||:||.::||||::::|:||..::..|.:||::...
Mosquito   201 LLITNIWLKLEWNDMNVRWNSSEYGGVRDLRIPPHRLWKPDVLMYNSADEGFDGTYPTNVVVRNN 265

  Fly   138 GEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTW 202
            |..|:|||.|::|:|.||:|:||||.|.|.|||||||::|.|:.|.| .:::..|:|.:..:|.|
Mosquito   266 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL-QDESGGDISSFITNGEW 329

  Fly   203 DIIEVPAYLN-VYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGE 266
            :::.||...| :|......| ..||||.|:||||||:|..|||:|.|||:.:.:|.|.||.::||
Mosquito   330 ELLGVPGKRNEIYYNCCPEP-YIDITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPPDSGE 393

  Fly   267 KVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTH 331
            |::||::|||||.|||.:|::.:|.||..:||:..|......|...|::.|::|:|::.|...||
Mosquito   394 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNSDTH 458

  Fly   332 RMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAI----- 391
            .|..:||.:||.:||..|.|.||.:               .:|||...:..|..|.:..:
Mosquito   459 EMSEWIRVVFLIWLPFILRMSRPGE---------------PYPHPCRPTVDEKNKQLQEVEMRER 508

  Fly   392 GGKQSKMEVMELSDLHHPNCKIN-------------RKVNSG-----------------GELGLG 426
            ..|.....|:::.|....|.:.|             |:...|                 |.:..|
Mosquito   509 SSKSLLANVLDIDDDFRCNHRCNTLPHNPTYYRTVYRQGEDGSVGPIGATDTIGRSAGLGTISAG 573

  Fly   427 DGCRRESESSDSILLSP---EASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFF 488
            .|...|:.||.:.|.|.   |.:...:.:.:|.:.||.||...:...:||:.|||:|||.|.||.
Mosquito   574 GGRLHETVSSHTCLSSSAEYELALILKELRYITDQLRKEDETGEVTREWKFAAMVVDRLCLIIFT 638

  Fly   489 IVTTAGTVGILMDAPH 504
            :.|...|:.:|..|||
Mosquito   639 LFTIIATLAVLFSAPH 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	189/530 (36%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	90/209 (43%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
LOC1270457	XP_061509986.1	None