Protein Alignment nAChRbeta1 and CHRNG

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_005190.4
• Gene: CHRNG / 1146
• HGNCID: 1967
• Length: 517
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 175/509 - (34%)
• Similarity: 270/509 - (53%)
• Gaps: 42/509 - (8%)

  Fly    13 ILVLVAFSL-VSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKS 76
            :|:|:|..| ......||||:.||.:.|:..:||.:..:..|.|...|....||::||:.:.:.:
Human    10 LLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTT 74

  Fly    77 NVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVL 141
            |||:.:.|.||:|:||..||.|:.|||:|...||:|||||.||.||.:||....|||:.|.|.:.
Human    75 NVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIY 139

  Fly   142 WVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN------FVDLSDYWKSG 200
            |:||||::|:|:|.|||||||.|.|.:.|.|.|::.:::.|.|.....      |:|...:.::|
Human   140 WLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENG 204

  Fly   201 TWDIIEVPAYLNVYEGDSNHPTE----TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLP 261
            .|.|...||.:.:   |...|.:    ..:.||::|:||.|||.:|:|.|.||||.:.:|:.:||
Human   205 EWAIQHRPAKMLL---DPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLP 266

  Fly   262 AEA-GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNF 325
            |:| |:|.|:.|::||:..|||.||:|.:|.||..:|||:|||.|..::..:.::..|:::|.:.
Human   267 AKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSL 331

  Fly   326 RGPRTHRMPMYIRSIFLHYLPAFLFMK-RP------RKTRLRWMMEMPGMSMPAHPHPSYGSPAE 383
            |.|.||.|...:|.:||..||..|.|. ||      :.|:.|......|.|:      :.|....
Human   332 RSPHTHSMARGVRKVFLRLLPQLLRMHVRPLAPAAVQDTQSRLQNGSSGWSI------TTGEEVA 390

  Fly   384 LPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKA 448
            |....|.:..:|.:.:.:..:.|        .|:..|.||||...|....::      :|.....
Human   391 LCLPRSELLFQQWQRQGLVAAAL--------EKLEKGPELGLSQFCGSLKQA------APAIQAC 441

  Fly   449 TEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502
            .||...||.....:..:....|:|..|..|:||:.......:...||.||.:.|
Human   442 VEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLSLFICGTAGIFLMA 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	174/505 (34%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	85/218 (39%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
CHRNG	NP_005190.4	LGIC_ECD_nAChR_G	49..241	CDD:349830	76/194 (39%)
		Cys-loop	150..164	CDD:349830	10/13 (77%)
		Neur_chan_memb	248..492	CDD:460753	79/263 (30%)