Protein Alignment nAChRbeta1 and CHRNE

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000071.1
• Gene: CHRNE / 1145
• HGNCID: 1966
• Length: 493
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 168/500 - (33%)
• Similarity: 269/500 - (53%)
• Gaps: 42/500 - (8%)

  Fly    15 VLVAFSLVS---ASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKS 76
            ||:...|:.   ...:|.||...||..|:...|||:.....|.:...:....||::|||.:.:.:
Human     8 VLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTT 72

  Fly    77 NVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVL 141
            :||:.:.|.||:|.:.:.|:|||..||:|.:.||.|:|||.||.||.:.|.|.:|||:|..|.|.
Human    73 SVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVT 137

  Fly   142 WVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQV--SLALYN-----NKNFVDLSDYWKS 199
            |:|||||:|.|.::|||||||.|.|.:.|.|.|:|.::|  :.|:.|     ||..:|...|.::
Human   138 WLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTEN 202

  Fly   200 GTWDIIEVPAYLNVYEGD-SNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAE 263
            |.|.|...|..:..:.|. ::.|.|||:.:.:|||||.|||.:|:|:|.||||.|.:|.::|||:
Human   203 GEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQ 267

  Fly   264 A-GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRG 327
            | |:|.|:.|::||:..|||.|:::.:|.|||.:||:.::|:|..::.|:.::..||::|.:.|.
Human   268 AGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRT 332

  Fly   328 PRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIG 392
            |.||.|...:|.:.|..||..|                  .|.|....|...||   |:..|::|
Human   333 PTTHAMSPRLRHVLLELLPRLL------------------GSPPPPEAPRAASP---PRRASSVG 376

  Fly   393 GKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAE 457
            ......|::    |..|..::   |..|.....|.......:|..:  .:||.....:||.|:||
Human   377 LLLRAEELI----LKKPRSEL---VFEGQRHRQGTWTAAFCQSLGA--AAPEVRCCVDAVNFVAE 432

  Fly   458 HLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502
            ..|:::...:...||..:...:|.:..:...::.:.|:..|.:.|
Human   433 STRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGA 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	167/496 (34%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	87/216 (40%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
CHRNE	NP_000071.1	LGIC_ECD_nAChR_E	49..239	CDD:349831	77/189 (41%)
		Cys-loop	148..162	CDD:349831	9/13 (69%)
		Neur_chan_memb	247..474	CDD:460753	71/256 (28%)