Protein Alignment nAChRbeta1 and Chrng

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_006529141.1
• Gene: Chrng / 11449
• MGIID: 87895
• Length: 541
• Species: Mus musculus
• Alignment Length: 504
• Identity: 172/504 - (34%)
• Similarity: 262/504 - (51%)
• Gaps: 61/504 - (12%)

  Fly    28 EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWD 92
            ||||:.||.|.|:..:||.:..:..|.|...|....||::||:.:.:.:|||:.:.|.||:|:||
Mouse    48 EERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWD 112

  Fly    93 EADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVT 157
            ..||.|:.:||:|...||:|||||.||.||.:||....|||:.|.|.:.|:||||::|||:|.||
Mouse   113 PKDYEGLWILRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSSCSISVT 177

  Fly   158 YFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN------FVDLSDYWKSGTWDIIEVPAYLNVYEG 216
            |||||.|.|.:.|.|.|::..:::|.|.....      |:|...:.::|.|.|...||.:.:
Mouse   178 YFPFDWQNCSLVFQSQTYSTSEINLQLSQEDGQAIEWIFIDPEAFTENGEWAIRHRPAKMLL--- 239

  Fly   217 DSNHPTE----TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA-GEKVTLGISILL 276
            ||..|.|    ..:.||::|:||.|||.:|:|.|.||||.:.:|:::|||:| |:|.|:..::||
Mouse   240 DSVAPAEEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCTVATNVLL 304

  Fly   277 SLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIF 341
            :..|||.||:|.:|.||..:|||:|||.|..::..:.::.:|:::|.:.|.|.||.|...:|.:|
Mouse   305 AQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSPHTHSMARGVRKVF 369

  Fly   342 LHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAEL-PKHISAIGGKQSKMEVM--EL 403
            |..||..|.|                     |..|.  :||.: ........|..|...:|  |.
Mouse   370 LRLLPQLLRM---------------------HVRPL--APAAVQDARFRLQNGSSSGWPIMAREE 411

  Fly   404 SDLHHPNCK--------------INRKVNSGGELGLGDGCRRESESSDSI-LLSPEASKATEAVE 453
            .||..|..:              :..|:.:|.|:      |:..|...|: ..||......:|..
Mouse   412 GDLCLPRSELLFRQRQRNGLVQAVLEKLENGPEV------RQSQEFCGSLKQASPAIQACVDACN 470

  Fly   454 FIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502
            .:|...|.:..:....|:|..|..|:||:.......:...||.||.:.|
Mouse   471 LMARARRQQSHFDSGNEEWLLVGRVLDRVCFLAMLSLFICGTAGIFLMA 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	171/500 (34%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	88/217 (41%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
Chrng	XP_006529141.1	LGIC_ECD_nAChR_G	71..263	CDD:349830	78/194 (40%)
		Cys-loop	172..186	CDD:349830	10/13 (77%)
		Neur_chan_memb	270..516	CDD:460753	77/274 (28%)