DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta1 and Chrne

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_006532069.1	Gene:	Chrne / 11448	MGIID:	87894	Length:	494	Species:	Mus musculus

Alignment Length:	520	Identity:	171/520 - (32%)
Similarity:	274/520 - (52%)	Gaps:	60/520 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQI 73
            ||.::|:|..|.......:|..|...||..|:...|||:.....|.:...:....||::|||.:.
Mouse     5 LLGALLLLTLFGRSQGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEET 69

  Fly    74 MKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTG 138
            :.::||:.:.|:||:|.:.:.|:.|:|:||:|.:.||.|:|||.||.||.:.|.|.||||:|..|
Mouse    70 LTTSVWIGIDWHDYRLNYSKDDFAGVGILRVPSEHVWLPEIVLENNIDGQFGVAYDSNVLVYEGG 134

  Fly   139 EVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL-------YNNKNFVDLSDY 196
            .|.|:|||||:|:|.::|||||||.|.|.:.|.|.|:|.::|....       ..||..:|.:.:
Mouse   135 YVSWLPPAIYRSTCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNTINKIDIDTAAF 199

  Fly   197 WKSGTWDIIEVPAYLNVYEGDSNH-PTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYL 260
            .::|.|.|...|..:..|||.|.. |.|||:.:.:|||||.|||.:|:|:|.||||.|.:|.::|
Mouse   200 TENGEWAIDYCPGMIRRYEGGSTEGPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFL 264

  Fly   261 PAEA-GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWN 324
            ||:| |:|.|:.|::||:..|||.|:::.:|.|||.:||:.:||:|..::.|:.::..||::|.:
Mouse   265 PAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVS 329

  Fly   325 FRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHIS 389
            .|.|.||.....:|.|.|..||..|                 |.|.|.. .|...|||   :..|
Mouse   330 LRTPTTHATSPRLRQILLELLPRLL-----------------GSSPPPE-DPRTASPA---RRAS 373

  Fly   390 AIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILL-------SPEASK 447
            ::|......|::    |..|..::           :.:|.|....:..:..|       :||...
Mouse   374 SVGILLRAEELI----LKKPRSEL-----------VFEGQRHRHGTWTAAALCQNLGAAAPEIRC 423

  Fly   448 ATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM--------DAPH 504
            ..:||.|:||..|:::...:...||..:...:|.:..:...::.:.|:..|.:        |.|:
Mouse   424 CVDAVNFVAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFLGGYFNQVPDLPY 488

Fly 505 504
Mouse 489 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	169/506 (33%)
		Neur_chan_LBD	28..236	CDD:280998	86/215 (40%)
		Neur_chan_memb	243..498	CDD:280999	72/262 (27%)
Chrne	XP_006532069.1	LGIC_ECD_nAChR_E	49..239	CDD:349831	77/189 (41%)
Chrne	XP_006532069.1	Neur_chan_memb	247..474	CDD:367256	72/262 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810