Protein Alignment nAChRbeta1 and Chrnd

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_067611.2
• Gene: Chrnd / 11447
• MGIID: 87893
• Length: 520
• Species: Mus musculus
• Alignment Length: 544
• Identity: 199/544 - (36%)
• Similarity: 306/544 - (56%)
• Gaps: 76/544 - (13%)

  Fly    10 LCSILVLVAFSLVSASEDEERLVRDLF--RGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQ 72
            |.:.||:.|........:|:||::.||  :||:|.:|||.....||.|...|....||::.|..:
Mouse    10 LLAALVVCALPGSWGLNEEQRLIQHLFNEKGYDKDLRPVARKEDKVDVALSLTLSNLISLKEVEE 74

  Fly    73 IMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPT 137
            .:.:|||:...|.|.:||||..|:|.|.|||||||.||.|:|||.||.||::::.|..|||:|.:
Mouse    75 TLTTNVWIDHAWVDSRLQWDANDFGNITVLRLPPDMVWLPEIVLENNNDGSFQISYACNVLVYDS 139

  Fly   138 GEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL----YNNKNF------VD 192
            |.|.|:||||::|||.|.|||||||.|.|.:||.|..:...:::|:|    .||:::      :|
Mouse   140 GYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQEEENNRSYPIEWIIID 204

  Fly   193 LSDYWKSGTWDIIEVPAYLNVYEGDSNHPTET----DITFYIIIRRKTLFYTVNLILPTVLISFL 253
            ...:.::|.|:|:...|.|||   |.:.|.::    |:|||:|||||.|||.:|:::|.|||||:
Mouse   205 PEGFTENGEWEIVHRAAKLNV---DPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVLISFM 266

  Fly   254 CVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTV 318
            ..||||||.:.|||.::.||:||:..|||||:||.||.||:.:||:.|:|||..::.|:.:::.|
Mouse   267 INLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVVVICV 331

  Fly   319 IIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAE 383
            |::|.:||.|.||.:...::..||..||..|.|.||.:       |.||             |..
Mouse   332 IVLNIHFRTPSTHVLSEGVKKFFLETLPKLLHMSRPAE-------EDPG-------------PRA 376

  Fly   384 LPKHISAIG---------GKQSKMEVM--ELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSD 437
            |.:..|::|         ..:|:.::|  :.|:.|    .:.|::.:         .||...||:
Mouse   377 LIRRSSSLGYICKAEEYFSLKSRSDLMFEKQSERH----GLARRLTT---------ARRPPASSE 428

  Fly   438 SIL--LSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            .:.  |..|...|.:...||..|:|:::.|.:.:::|..||..:|||.|::...|...||..|.:
Mouse   429 QVQQELFNEMKPAVDGANFIVNHMRDQNSYNEEKDNWNQVARTVDRLCLFVVTPVMVVGTAWIFL 493

  Fly   501 ----DAPHI-------FEYVDQDR 513
                :.|.:       |.|.:||:
Mouse   494 QGVYNQPPLQPFPGDPFSYSEQDK 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	194/518 (37%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	97/224 (43%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
Chrnd	NP_067611.2	LGIC_ECD	29..249	CDD:475126	96/222 (43%)
		Neur_chan_memb	256..492	CDD:460753	87/268 (32%)