Protein Alignment nAChRbeta1 and Chrnb2

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_033732.2
• Gene: Chrnb2 / 11444
• MGIID: 87891
• Length: 501
• Species: Mus musculus
• Alignment Length: 516
• Identity: 216/516 - (41%)
• Similarity: 299/516 - (57%)
• Gaps: 71/516 - (13%)

  Fly    12 SILVLVAFSL------VSASEDEERLVRDLF--RGYNKLIRPVQNMTQKVGVRFGLAFVQLINVN 68
            |:.:|.:|.|      |..::.|||||..|.  ..|||||||..|.::.|.|:..::..|||:|:
Mouse     7 SMALLFSFGLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVH 71

  Fly    69 EKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVL 133
            |:.|||.:||||...|.||:|.|...|:..:..:|||...:|.||:||:|||||.|||.:.||.:
Mouse    72 EREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAV 136

  Fly   134 IYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWK 198
            :...|.:.|:|||||:|:|.|:|.:||||||.|.|||.|||::..::.|.|  ..:...|.|:..
Mouse   137 VSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL--KSDVASLDDFTP 199

  Fly   199 SGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAE 263
            ||.||||.:|...|....||   |..|||:..|||||.||||:|||:|.|||:.|.:||||||::
Mouse   200 SGEWDIIALPGRRNENPDDS---TYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSD 261

  Fly   264 AGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGP 328
            .|||:||.||:||:|.|||||:|||:|||||.:||:.|||:||.::.|.||:.:|.::|.:.|.|
Mouse   262 CGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSP 326

  Fly   329 RTHRMPMYIRSIFLHYLPAFLFMKRPR------KTRLR------------WMMEMPGMSMPAHPH 375
            .||.|..:::.:||..||..||:::||      :.|||            :..|.|.    |.|.
Mouse   327 TTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRLRLRRRQREREGAGTLFFREGPA----ADPC 387

  Fly   376 PSYGSPAELPKHISAIGGKQSKMEVMELSDLHHP-NCKINRKVNSGGELGLGDGCRRESESSDSI 439
            ..:.:||.:.   ...|..|::.....|.....| :|                |.|
Mouse   388 TCFVNPASMQ---GLAGAFQAEPAAAGLGRSMGPCSC----------------GLR--------- 424

  Fly   440 LLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
                   :|.:.|.|||:|:|:||.....||||||||||||||.|:||..|...||:|:.:
Mouse   425 -------EAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	216/514 (42%)
		Neur_chan_LBD	28..236	CDD:280998	98/209 (47%)
		Neur_chan_memb	243..498	CDD:280999	106/273 (39%)
Chrnb2	NP_033732.2	LIC	29..478	CDD:273305	211/492 (43%)
		Neur_chan_LBD	29..234	CDD:280998	98/209 (47%)
		Neur_chan_memb	241..477	CDD:280999	107/274 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780