Protein Alignment nAChRbeta1 and Chrnb1

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_033731.3
• Gene: Chrnb1 / 11443
• MGIID: 87890
• Length: 501
• Species: Mus musculus
• Alignment Length: 501
• Identity: 191/501 - (38%)
• Similarity: 290/501 - (57%)
• Gaps: 53/501 - (10%)

  Fly    25 SEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQL 89
            ||.|.:|::.||..|:..:||.:.:..:|||..||...|||::|||::.|.:.|:|.|.|.||:|
Mouse    24 SEAEGQLIKKLFSNYDSSVRPAREVGDRVGVSIGLTLAQLISLNEKDEEMSTKVYLDLEWTDYRL 88

  Fly    90 QWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTI 154
            .||.|::.||..||:..:.||.||:||.||.|||::|....||::...|.|.|.||.:|:|||:|
Mouse    89 SWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDINVVVSFEGSVRWQPPGLYRSSCSI 153

  Fly   155 DVTYFPFDQQTCIMKFGSWTFNGDQVSLAL-------YNNKNFVDLSDYWKSGTWDIIEVPAYLN 212
            .|||||||.|.|.|.|.|::::..:|||..       ...:.::....:.::|.|:||..|:.|.
Mouse   154 QVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGLDPEGEERQEVYIHEGTFIENGQWEIIHKPSRLI 218

  Fly   213 VYEGDSNHPTE---TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISI 274
            ...||.....|   .::.||:|||||.|||.||:|.|.:||:.|.:.|||||.:||||:.|.|..
Mouse   219 QLPGDQRGGKEGHHEEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFA 283

  Fly   275 LLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRS 339
            ||:|.|||||::..:|.|||.:|:|.|||:||.::.|.|::::|:::|.:.|.|.||:||.::|.
Mouse   284 LLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPFWVRQ 348

  Fly   340 IFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIG-GKQSKMEVMEL 403
            ||:|.||.:|.:|||:..|    .::|      .||.|. ||.      |..| |..........
Mouse   349 IFIHKLPPYLGLKRPKPER----DQLP------EPHHSL-SPR------SGWGRGTDEYFIRKPP 396

  Fly   404 SDLHHPNCKINRKVNSGGELGLGDGCRRESESSD----------SILLSPEASKATEAVEFIAEH 458
            ||...|  |:||             .:.||.:.|          ::.|..|..:...::.::|..
Mouse   397 SDFLFP--KLNR-------------FQPESSAPDLRRFIDGPTRAVGLPQELREVISSISYMARQ 446

  Fly   459 LRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPH 504
            |:.::.:...:|||::||||:|||.|:.|.:.|:.||:.|.:||.:
Mouse   447 LQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFLDATY 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	189/495 (38%)
		Neur_chan_LBD	28..236	CDD:280998	87/217 (40%)
		Neur_chan_memb	243..498	CDD:280999	93/265 (35%)
Chrnb1	NP_033731.3	LIC	24..488	CDD:273305	189/495 (38%)
		Neur_chan_LBD	27..245	CDD:280998	87/217 (40%)
		Neur_chan_memb	252..487	CDD:280999	93/266 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..382		9/36 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4377
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.720