DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRbeta1 and CHRND

DIOPT Version :9

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_000742.1 Gene:CHRND / 1144 HGNCID:1965 Length:517 Species:Homo sapiens


Alignment Length:522 Identity:195/522 - (37%)
Similarity:293/522 - (56%) Gaps:74/522 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 CKSWLLCSILVLVAFSLVSASEDEERLVRDLF--RGYNKLIRPVQNMTQKVGVRFGLAFVQLINV 67
            |.||.|               .:||||:|.||  :||||.:|||.:..:.|.|...|....||::
Human    17 CGSWGL---------------NEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISL 66

  Fly    68 NEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNV 132
            .|..:.:.:|||:...|.|.:|:|:..::|.|.|||||||.||.|:|||.||.||::::.|..||
Human    67 KEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNV 131

  Fly   133 LIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL----YNNKNF--- 190
            |:|..|.|.|:||||::|||.|.|||||||.|.|.:||.|..:...:::|:|    ..|:.:   
Human   132 LVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVE 196

  Fly   191 ---VDLSDYWKSGTWDIIEVPAYLNV-YEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLIS 251
               :|...:.::|.|:|:..||.:|| .....:.|:..|||||:|||||.|||.:|:::|.||||
Human   197 WIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLIS 261

  Fly   252 FLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILV 316
            |:..|||||||::|||.::.||:||:..|||||:||.||.||:.:|||.|:|||..::.|:.:::
Human   262 FMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVI 326

  Fly   317 TVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSP 381
            .||::|.:||.|.||.:...::.:||..||..|.|.|                 ||...|   ||
Human   327 CVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSR-----------------PAEDGP---SP 371

  Fly   382 AELPKHISAIG--GK-------QSKMEVM--ELSDLHHPNCKINRKVNSGGELGLGDGCRRESES 435
            ..|.:..|::|  .|       :|:.::|  :.|:.|    .:.|::.:         .||...|
Human   372 GALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERH----GLARRLTT---------ARRPPAS 423

  Fly   436 SDSIL--LSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGI 498
            |:...  |..|...|.:...||..|:|:::.|.:.::.|..||..:|||.|::...|...||..|
Human   424 SEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWI 488

  Fly   499 LM 500
            .:
Human   489 FL 490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:273305 193/517 (37%)
Neur_chan_LBD 28..236 CDD:280998 95/220 (43%)
Neur_chan_memb 243..498 CDD:280999 90/267 (34%)
CHRNDNP_000742.1 Neur_chan_LBD 25..246 CDD:308532 95/220 (43%)
Neur_chan_memb 253..489 CDD:308533 90/268 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.