Protein Alignment nAChRbeta1 and CHRND

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000742.1
• Gene: CHRND / 1144
• HGNCID: 1965
• Length: 517
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 195/522 - (37%)
• Similarity: 293/522 - (56%)
• Gaps: 74/522 - (14%)

  Fly     5 CKSWLLCSILVLVAFSLVSASEDEERLVRDLF--RGYNKLIRPVQNMTQKVGVRFGLAFVQLINV 67
            |.||.|               .:||||:|.||  :||||.:|||.:..:.|.|...|....||::
Human    17 CGSWGL---------------NEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISL 66

  Fly    68 NEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNV 132
            .|..:.:.:|||:...|.|.:|:|:..::|.|.|||||||.||.|:|||.||.||::::.|..||
Human    67 KEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNV 131

  Fly   133 LIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL----YNNKNF--- 190
            |:|..|.|.|:||||::|||.|.|||||||.|.|.:||.|..:...:::|:|    ..|:.:
Human   132 LVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVE 196

  Fly   191 ---VDLSDYWKSGTWDIIEVPAYLNV-YEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLIS 251
               :|...:.::|.|:|:..||.:|| .....:.|:..|||||:|||||.|||.:|:::|.||||
Human   197 WIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLIS 261

  Fly   252 FLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILV 316
            |:..|||||||::|||.::.||:||:..|||||:||.||.||:.:|||.|:|||..::.|:.:::
Human   262 FMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVI 326

  Fly   317 TVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSP 381
            .||::|.:||.|.||.:...::.:||..||..|.|.|                 ||...|   ||
Human   327 CVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSR-----------------PAEDGP---SP 371

  Fly   382 AELPKHISAIG--GK-------QSKMEVM--ELSDLHHPNCKINRKVNSGGELGLGDGCRRESES 435
            ..|.:..|::|  .|       :|:.::|  :.|:.|    .:.|::.:         .||...|
Human   372 GALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERH----GLARRLTT---------ARRPPAS 423

  Fly   436 SDSIL--LSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGI 498
            |:...  |..|...|.:...||..|:|:::.|.:.::.|..||..:|||.|::...|...||..|
Human   424 SEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWI 488

  Fly   499 LM 500
            .:
Human   489 FL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	193/517 (37%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	95/221 (43%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
CHRND	NP_000742.1	LGIC_ECD_nAChR_D	26..246	CDD:349829	94/219 (43%)
		Cys-loop	151..165	CDD:349829	10/13 (77%)
		Neur_chan_memb	253..489	CDD:460753	90/268 (34%)