DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta1 and CHRNB4

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_000741.1	Gene:	CHRNB4 / 1143	HGNCID:	1964	Length:	498	Species:	Homo sapiens

Alignment Length:	505	Identity:	209/505 - (41%)
Similarity:	302/505 - (59%)	Gaps:	40/505 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LVAFSLVS--------ASEDEERLVRDLFR--GYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEK 70
            ||.|.||:        .:..||:|:.||..  .||.||||..:.:|.:.::..|:..|||:|||:
Human     7 LVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNER 71

  Fly    71 NQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIY 135
            .|||.:||||:..|.||:|.|:.:.|.|:.:||:|..::|.|||||:|||||.|||...:|:::.
Human    72 EQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVR 136

  Fly   136 PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSG 200
            ..|.|||:|||||:|:|.|:|.|||||||.|.:||.|||::..::.:.|......:|  |:..||
Human   137 SNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMD--DFTPSG 199

  Fly   201 TWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG 265
            .|||:.:|....|...|   |:..|:|:..||:||.||||:|||:|.||.:.|.:||||||::.|
Human   200 EWDIVALPGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCG 261

  Fly   266 EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT 330
            ||:||.||:||:|..||||:|||:|||||.:|||.|||:||.::.|.||:.:|.::|.:.|.|.|
Human   262 EKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPST 326

  Fly   331 HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQ 395
            |.|..:::..|||.||.|||||||...           |.||...|    |::     |.:...:
Human   327 HTMAPWVKRCFLHKLPTFLFMKRPGPD-----------SSPARAFP----PSK-----SCVTKPE 371

  Fly   396 SKMEVMELSDLHHPNCKINRKVNSGGELGLGD---GCRRESESSDSILLSPEASKATEAVEFIAE 457
            :.......|:.:..:.......::..:...|.   ...|:.....|.....:..:|.|.|.|||:
Human   372 ATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQ 436

  Fly   458 HLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFE 507
            |::|:|......|||||||||:|||.|::|..|...||||:.:  |.:|:
Human   437 HMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFL--PPLFQ 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	207/496 (42%)
		Neur_chan_LBD	28..236	CDD:280998	94/209 (45%)
		Neur_chan_memb	243..498	CDD:280999	101/257 (39%)
CHRNB4	NP_000741.1	Neur_chan_LBD	5..480	CDD:332142	207/499 (41%)
CHRNB4	NP_000741.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..377		4/28 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.780