Protein Alignment nAChRbeta1 and CHRNB3

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000740.1
• Gene: CHRNB3 / 1142
• HGNCID: 1963
• Length: 458
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 197/501 - (39%)
• Similarity: 291/501 - (58%)
• Gaps: 68/501 - (13%)

  Fly    13 ILVLVAFSLVSA--------SEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNE 69
            :|||:...:.|:        :|:|:.|:|.||:||.|.:|||.:....:.|.|||...||::|:|
Human     6 MLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDE 70

  Fly    70 KNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLI 134
            |||:|.:||||:..|.|::|:|:..|||||..:::|.:.:|.||||||.||||.:|....:.|::
Human    71 KNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIV 135

  Fly   135 YPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKS 199
            ...|.|:|.|||.|:||||:|||:||||:|.|.|||||||::|..|.|.|.|..  ||..|::.:
Human   136 KSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINEN--VDRKDFFDN 198

  Fly   200 GTWDIIEVPAYL-NVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAE 263
            |.|:|:...... |..:|..::|.   ||:..::||..||||:.||:|.:.:|||.|||||||::
Human   199 GEWEILNAKGMKGNRRDGVYSYPF---ITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSD 260

  Fly   264 AGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGP 328
            .|||::|..|:|:||.||||::.:|:|.:|.|:|||.:||||..|..|:||:|||.:||.:.|..
Human   261 EGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSS 325

  Fly   329 RT-HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPH-PSYGSPAELPKHISAI 391
            .| |.|..:::.:||..||..|.||                     .| ..|.|| |..:....:
Human   326 STYHPMAPWVKRLFLQKLPKLLCMK---------------------DHVDRYSSP-EKEESQPVV 368

  Fly   392 GGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIA 456
            .||     |:|         |..:|..|.||.                :|.....||.:::.:|:
Human   369 KGK-----VLE---------KKKQKQLSDGEK----------------VLVAFLEKAADSIRYIS 403

  Fly   457 EHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502
            .|::.|....|..:|||:||.|:||:.|::|.||:..|:|.|...|
Human   404 RHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPA 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	196/497 (39%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	95/209 (45%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
CHRNB3	NP_000740.1	LIC	23..449	CDD:455710	192/482 (40%)