Protein Alignment nAChRbeta1 and CHRNB2

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000739.1
• Gene: CHRNB2 / 1141
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 215/515 - (41%)
• Similarity: 296/515 - (57%)
• Gaps: 70/515 - (13%)

  Fly    13 ILVLVAFSL------VSASEDEERLVRDLF--RGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNE 69
            :.:|:.|.|      |..::.|||||..|.  ..|||||||..|.::.|.|:..::..|||:|:|
Human     8 VALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHE 72

  Fly    70 KNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLI 134
            :.|||.:||||...|.||:|.|...::..:..:|||...:|.||:||:|||||.|||.:.||.::
Human    73 REQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVV 137

  Fly   135 YPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKS 199
            ...|.:.|:|||||:|:|.|:|.:||||||.|.|||.|||::..::.|.|  ......|.|:..|
Human   138 SYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL--KSEVASLDDFTPS 200

  Fly   200 GTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA 264
            |.|||:.:|...|....||   |..|||:..|||||.||||:|||:|.|||:.|.:||||||::.
Human   201 GEWDIVALPGRRNENPDDS---TYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC 262

  Fly   265 GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPR 329
            |||:||.||:||:|.|||||:|||:|||||.:||:.|||:||.::.|.||:.:|.::|.:.|.|.
Human   263 GEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT 327

  Fly   330 THRMPMYIRSIFLHYLPAFLFMKRPR------KTRLR------------WMMEMPGMSMPAHPHP 376
            ||.|..:::.:||..|||.|||::||      :.|||            :..|.||    |....
Human   328 THTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPG----ADSCT 388

  Fly   377 SYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGC-RRESESSDSIL 440
            .:.:.|.:.....|.|.:.:                   .|...|..|...|| .||
Human   389 CFVNRASVQGLAGAFGAEPA-------------------PVAGPGRSGEPCGCGLRE-------- 426

  Fly   441 LSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
                   |.:.|.|||:|:|:||......|||||||||||||.|:||..|...||:|:.:
Human   427 -------AVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	215/513 (42%)
		Neur_chan_LBD	28..236	CDD:280998	96/209 (46%)
		Neur_chan_memb	243..498	CDD:280999	108/273 (40%)
CHRNB2	NP_000739.1	LIC	29..479	CDD:273305	211/492 (43%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	94/207 (45%)
		Cys-loop	155..169	CDD:349826	9/13 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.780