Protein Alignment nAChRbeta1 and CHRNB1

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000738.2
• Gene: CHRNB1 / 1140
• HGNCID: 1961
• Length: 501
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 198/494 - (40%)
• Similarity: 289/494 - (58%)
• Gaps: 33/494 - (6%)

  Fly    22 VSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYD 86
            |..||.|.||...||.||:..:||.:.:..:|.|..||...|||::|||::.|.:.|:|.|.|.|
Human    21 VRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTD 85

  Fly    87 YQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSS 151
            |:|.||.|::.||..||:..:.||.||:||.||.|||::|....:|::...|.|.|.||.||:||
Human    86 YRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSS 150

  Fly   152 CTIDVTYFPFDQQTCIMKFGSWTFNGDQVSL-------ALYNNKNFVDLSDYWKSGTWDIIEVPA 209
            |:|.|||||||.|.|.|.|.|::::..:|||       ...:.:..:....:.::|.|:||..|:
Human   151 CSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPS 215

  Fly   210 YLNVYEGDSNHPTE---TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLG 271
            .|....||.....|   .::.||:|||||.|||.||:|.|.:||:.|.:.|||||.:||||:.|.
Human   216 RLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLS 280

  Fly   272 ISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMY 336
            |..||:|.|||||::..:|.|||.:|:|.|||:||.::.|.|::::|:::|.:.|.|.||:||::
Human   281 IFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLW 345

  Fly   337 IRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIG-GKQSKMEV 400
            :|.||:|.||.:|.:|||:..|         ..||..||.|  ||.      |..| |.......
Human   346 VRQIFIHKLPLYLRLKRPKPER---------DLMPEPPHCS--SPG------SGWGRGTDEYFIR 393

  Fly   401 MELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLY 465
            ...||...|  |.||   ...||...|..|.....:.::.|.||..:...::.:||..|:.::.:
Human   394 KPPSDFLFP--KPNR---FQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDH 453

  Fly   466 IQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPH 504
            ...:|||::||||:|||.|:.|.|.|:.||:.|.:||.:
Human   454 DALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATY 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	196/488 (40%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	88/218 (40%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
CHRNB1	NP_000738.2	LGIC_ECD_nAChR_B1	27..245	CDD:349825	88/217 (41%)
		Cys-loop	151..165	CDD:349825	10/13 (77%)
		Neur_chan_memb	252..487	CDD:460753	98/256 (38%)