Protein Alignment nAChRbeta1 and CHRNA5

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000736.2
• Gene: CHRNA5 / 1138
• HGNCID: 1959
• Length: 468
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 186/499 - (37%)
• Similarity: 280/499 - (56%)
• Gaps: 95/499 - (19%)

  Fly    23 SASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDY 87
            |.::.|:.|::|||:.|.:.:|||:::..|:.::||||..||::|:||||:|.:||||:..|.|.
Human    42 SIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDV 106

  Fly    88 QLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSC 152
            :|:|:..|||||.|:|:|.|.||.||||||:||||.:|......|:.| .|.|.|.|||.|:|||
Human   107 KLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRY-NGTVTWTPPANYKSSC 170

  Fly   153 TIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGD 217
            |||||:||||.|.|.|||||||::|.||.:.|.:..  ||..|::.:|.|:|:..       .|.
Human   171 TIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQD--VDKRDFFDNGEWEIVSA-------TGS 226

  Fly   218 SNHPTET-----DITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLS 277
            ..:.|::     .:|:..:|:|..||||:.||:|.:.:|||.|||||||:..|||:.|..|:|:|
Human   227 KGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVS 291

  Fly   278 LVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHR-MPMYIRSIF 341
            |.||||::.:|:|.:|.|:|||.:||:||.|..|:||:|||..||.:.|...||. |...:|.||
Human   292 LTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIF 356

  Fly   342 LHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDL 406
            ||.||..|.|:                   :|
Human   357 LHTLPKLLCMR-------------------SH--------------------------------- 369

  Fly   407 HHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASK-----ATEAVEFIAEHLRNEDLYI 466
                  ::|......|...|.|              |::|:     |.:::.:|..|:..|:...
Human   370 ------VDRYFTQKEETESGSG--------------PKSSRNTLEAALDSIRYITRHIMKENDVR 414

  Fly   467 QTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVD 510
            :..||||::|.|:||:.|:.|..|:..|::|:.:  |.|:::.:
Human   415 EVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFV--PVIYKWAN 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	184/487 (38%)
		Neur_chan_LBD	28..236	CDD:280998	97/212 (46%)
		Neur_chan_memb	243..498	CDD:280999	81/260 (31%)
CHRNA5	NP_000736.2	LIC	39..449	CDD:273305	184/490 (38%)
		Neur_chan_LBD	47..250	CDD:280998	97/212 (46%)
		Neur_chan_memb	257..447	CDD:280999	82/261 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820