DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta1 and CHRNA4

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_000735.1	Gene:	CHRNA4 / 1137	HGNCID:	1958	Length:	627	Species:	Homo sapiens

Alignment Length:	622	Identity:	244/622 - (39%)
Similarity:	341/622 - (54%)	Gaps:	143/622 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLCSILVLVAFSLVSASED-------EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLIN 66
            ||..:|:|:...|:.||..       ||||::.||.||||..|||.|::..|.|||||:..|||:
Human    11 LLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLID 75

  Fly    67 VNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSN 131
            |:||||:|.:|||::..|:||:|:||.|||..:..:|:|.:.:|:|||||:|||||::.|.:.:.
Human    76 VDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTK 140

  Fly   132 VLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDY 196
            ..::..|.|.|.|||||:|||:||||:||||||.|.|||||||:  |:..:.|.|..:.||..|:
Human   141 AHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTY--DKAKIDLVNMHSRVDQLDF 203

  Fly   197 WKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLP 261
            |:||.|.|::.....|..:.:.......|||:..:|||..||||:|||:|.:|||.|.|||||||
Human   204 WESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLP 268

  Fly   262 AEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFR 326
            :|.|||:||.||:||||.|||||:::|:|.||||:|||.:|||||.|..|:||::||.::|.:.|
Human   269 SECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHR 333

  Fly   327 GPRTHRMPMYIRSIFLHYLPAFLFMKRPR--KTRLRWMME------------------------- 364
            .||||.||.::|.:||..:|..|.||||.  |...|.::|
Human   334 SPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGT 398

  Fly   365 -----------MPGMSMPAHPHPSYGSPA-ELPKHISAIGGKQSKMEVMELSDLHHPN---CK-- 412
                       :| :.:||.|.||..||: :||        .|..:|..:.|.  ||:   |:
Human   399 QSLHPPSPSFCVP-LDVPAEPGPSCKSPSDQLP--------PQQPLEAEKASP--HPSPGPCRPP 452

  Fly   413 --------------INRKVNSGGELGLG----------------------DG------------- 428
                          ..:.::|.||...|                      ||
Human   453 HGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHS 517

  Fly   429 ---------------CRRESES-SDS--------------ILLSPEASKATEAVEFIAEHLRNED 463
                           |::|..| |.|              :.|||..::|.|.|::||:||:.||
Human   518 AELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAED 582

  Fly   464 LYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            .....:||||||||||||:.|::|.||...||||:.:
Human   583 TDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	244/620 (39%)
		Neur_chan_LBD	28..236	CDD:280998	102/207 (49%)
		Neur_chan_memb	243..498	CDD:280999	129/377 (34%)
CHRNA4	NP_000735.1	Neur_chan_LBD	37..243	CDD:280998	102/207 (49%)
		Neur_chan_memb	250..618	CDD:280999	130/378 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..481		19/109 (17%)
		Ten_N	<423..>572	CDD:284015	26/158 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..561		7/64 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H592
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820