Protein Alignment nAChRbeta1 and CHRNA3

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000734.2
• Gene: CHRNA3 / 1136
• HGNCID: 1957
• Length: 505
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 223/502 - (44%)
• Similarity: 324/502 - (64%)
• Gaps: 33/502 - (6%)

  Fly    10 LCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIM 74
            |..:|:|....:..|||.|.||...||..||::||||.|::..|.:.|.::..||:.|:|.||||
Human    17 LLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIM 81

  Fly    75 KSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGE 139
            ::|:||:.:|.||:|:|:.:||||...:|:|..|:|||||||:|||.|:::|..|:..|:..|||
Human    82 ETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGE 146

  Fly   140 VLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDI 204
            |.|:||||::|||.|||||||||.|.|.||||||:::..::.|.|..:.  ::|.|||:||.|.|
Human   147 VTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSS--MNLKDYWESGEWAI 209

  Fly   205 IEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVT 269
            |:.|.|.:..:.:.......|||:.:.|||..||||:|||:|.:|||||.|||||||::.|||||
Human   210 IKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVT 274

  Fly   270 LGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMP 334
            |.||:||||.||||::::.:|.||||:|||.:|||||.|..|:||::||.::|.::|.|.||.||
Human   275 LCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMP 339

  Fly   335 MYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSK-- 397
            .:::::||:.||..:||.||....          .....|.|.||  ||| .:::.....:||
Human   340 SWVKTVFLNLLPRVMFMTRPTSNE----------GNAQKPRPLYG--AEL-SNLNCFSRAESKGC 391

  Fly   398 MEVMELSD-----LHHPNCKINRKVNSGGELGLGDGCRRESESSDSIL----LSPEASKATEAVE 453
            .|.....|     .||...||:   |....|....    .|||.|::|    ||||..:|.::|:
Human   392 KEGYPCQDGMCGYCHHRRIKIS---NFSANLTRSS----SSESVDAVLSLSALSPEIKEAIQSVK 449

  Fly   454 FIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            :|||:::.::...:.::|||||||||||:.|::|.:|...||.|:.:
Human   450 YIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	223/500 (45%)
		Neur_chan_LBD	28..236	CDD:280998	99/207 (48%)
		Neur_chan_memb	243..498	CDD:280999	112/265 (42%)
CHRNA3	NP_000734.2	Neur_chan_LBD	30..496	CDD:332142	220/487 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920