Protein Alignment nAChRbeta1 and CHRNA2

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_000733.2
• Gene: CHRNA2 / 1135
• HGNCID: 1956
• Length: 529
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 228/493 - (46%)
• Similarity: 312/493 - (63%)
• Gaps: 40/493 - (8%)

  Fly    23 SASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDY 87
            |.:|.|:||.:.||||||:..|||.|.:..|.|||||:..|||:|:||||:|.:||||:..|.||
Human    54 SHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDY 118

  Fly    88 QLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSC 152
            :|:|:..|:|.|..||:|.:.:|.|||||:|||||.:.|.:.:...::.||.|.|||||||:|||
Human   119 KLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSC 183

  Fly   153 TIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGD 217
            :||||:||||||.|.|||||||:  |:..:.|...:..|||.|||:||.|.|:......|..:.|
Human   184 SIDVTFFPFDQQNCKMKFGSWTY--DKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYD 246

  Fly   218 SNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFL 282
            .......|:|:..:|||..||||:|||:|.:|||.|.|||||||::.|||:||.||:||||.|||
Human   247 CCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFL 311

  Fly   283 LLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPA 347
            ||:::|:|.||||:|||.:|||||.|..|:||::||.::|.:.|.|.||.||.::|...|..:|.
Human   312 LLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPR 376

  Fly   348 FLFMKRPRKTRLRWMMEMPGMSMPAHP-----HPSYGSPAELPKHISAIGGKQSKMEVMELSD-- 405
            :|.|.||          .|.:.: .||     .|||   ..|..::.|    :.:..|:|..|
Human   377 WLLMNRP----------PPPVEL-CHPLRLKLSPSY---HWLESNVDA----EEREVVVEEEDRW 423

  Fly   406 --LHH--PN----CKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNE 462
              ..|  |:    |. :..::||......:...:|.|    :||||...||.|.|.:||:|||:|
Human   424 ACAGHVAPSVGTLCS-HGHLHSGASGPKAEALLQEGE----LLLSPHMQKALEGVHYIADHLRSE 483

  Fly   463 DLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            |.....:||||||||||||:.|::|.||...||:|:.:
Human   484 DADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFL 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	228/491 (46%)
		Neur_chan_LBD	28..236	CDD:280998	105/207 (51%)
		Neur_chan_memb	243..498	CDD:280999	115/269 (43%)
CHRNA2	NP_000733.2	LIC	57..522	CDD:273305	227/490 (46%)
		Neur_chan_LBD	59..265	CDD:280998	105/207 (51%)
		Neur_chan_memb	272..520	CDD:280999	116/270 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820