Protein Alignment nAChRbeta1 and CHRNA1

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_016858745.1
• Gene: CHRNA1 / 1134
• HGNCID: 1955
• Length: 489
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 192/552 - (34%)
• Similarity: 292/552 - (52%)
• Gaps: 125/552 - (22%)

  Fly    12 SILVLVAFS--LVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIM 74
            ::||..|.|  ||..||.|.|||..||:.|:.::|||::..|.|.|..||..:|||||:|.|||:
Human    13 TVLVSSAVSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIV 77

  Fly    75 KSNVWLR---LV----------------------WYDYQLQWDEADYGGIGVLRLPPDKVWKPDI 114
            .:||.|:   :|                      |.||.|:|:..||||:..:.:|.:|:|:||:
Human    78 TTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDL 142

  Fly   115 VLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQ 179
            ||:|||||::.:...:.||:..||.:.|.||||::|.|.|.||:||||:|.|.||.|:||::|..
Human   143 VLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 207

  Fly   180 VSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLN--VYEGDSNHPTETDITFYIIIRRKTLFYTVN 242
            |  |:....:..|||::.:||.|.|.|...:.:  .|....:.| ..|||::.:::|..|::.||
Human   208 V--AINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTP-YLDITYHFVMQRLPLYFIVN 269

  Fly   243 LILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTF 307
            :|:|.:|.|||..||||||.::|||:||.||:||||.||||::.:::|.||..:|||.||:|||.
Human   270 VIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTM 334

  Fly   308 IMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLF---MKRPRKTRLRWMMEMPGMS 369
            :....||::|||:||.:.|.|.||.||.::|.:|:..:|..:|   ||||.:.
Human   335 VFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSRE------------ 387

  Fly   370 MPAHPHPSYGSPAELPKHISAIGGKQSK---MEVMELSDL-----------HHPNCKINRKVNSG 420
                                    ||.|   .|.:::||:           |.|
Human   388 ------------------------KQDKKIFTEDIDISDISGKPGPPPMGFHSP----------- 417

  Fly   421 GELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLY 485
                              ::..||...|.|.:::|||.::::........:|||||||:|.:.|.
Human   418 ------------------LIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLG 464

  Fly   486 IFFIVTTAGTVGILMDAPHIFEYVDQDRIIEI 517
            :|.:|...||:.:.           ..|:||:
Human   465 VFMLVCIIGTLAVF-----------AGRLIEL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	189/533 (35%)
		Neur_chan_LBD	28..236	CDD:280998	91/234 (39%)
		Neur_chan_memb	243..498	CDD:280999	87/271 (32%)
CHRNA1	XP_016858745.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880