Protein Alignment nAChRbeta1 and Chrna2

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_659052.1
• Gene: Chrna2 / 110902
• MGIID: 87886
• Length: 512
• Species: Mus musculus
• Alignment Length: 506
• Identity: 233/506 - (46%)
• Similarity: 322/506 - (63%)
• Gaps: 29/506 - (5%)

  Fly     8 WLLCSILV-LVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            :|.|.:|: .|.....|.:..|:||.:.||.|||:..|||.|.:..|.|||||:..|||:|:|||
Mouse    15 YLWCLLLMPAVLAQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKN 79

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136
            |:|.:||||:..|.||:|:||.|::|.|..||:|.:.:|.|||||:|||||.:.|.:.:...::.
Mouse    80 QMMTTNVWLKQEWNDYKLRWDPAEFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFF 144

  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201
            ||.|.|||||||:|||:||||:||||||.|.|||||||:  |:..:.|...:..|||.|||:||.
Mouse   145 TGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTY--DKAKIDLEQMERTVDLKDYWESGE 207

  Fly   202 WDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGE 266
            |.||......|..:.|.......|:|:|.:|||..||||:|||:|.:|||.|.|||||||:|.||
Mouse   208 WAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGE 272

  Fly   267 KVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTH 331
            |:||.||:||||.|||||:::|:|.||||:|||.:|||||.|..|:||::||.::|.:.|.|.||
Mouse   273 KITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 337

  Fly   332 RMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHP----HPSYGSPAELPKHISAIG 392
            .||.::|...|..:|.:|.|.||          :|.|.:...|    .|:|   ..|..::.|..
Mouse   338 NMPNWVRVALLGRVPRWLMMNRP----------LPPMELHGSPGLKLSPTY---HWLETNMDAEE 389

  Fly   393 GKQSKMEVMELSDLHHPNCKINRKVNSG-----GEL---GLGDGCRRESESSDSILLSPEASKAT 449
            .::::.|..|..|.:...|......:.|     |.|   .:|...:..|::|: |||||:..||.
Mouse   390 REETEEEEEEEEDENICMCAGLPDSSMGVLYGHGSLHLRAMGPEAKTPSQASE-ILLSPQIQKAL 453

  Fly   450 EAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            |.|.:||:|||:||.....:|||||||||:||:.|::|.||...||:|:.:
Mouse   454 EGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	233/504 (46%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	107/208 (51%)
		Cys-loop	152..166	CDD:349833	11/13 (85%)
Chrna2	NP_659052.1	LIC	15..505	CDD:455710	233/506 (46%)
		LGIC_ECD_nAChR_A2	36..242	CDD:349816	107/207 (52%)
		Cys-loop	160..174	CDD:349816	11/13 (85%)