DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta1 and Chrna5

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001360830.1	Gene:	Chrna5 / 110835	MGIID:	87889	Length:	467	Species:	Mus musculus

Alignment Length:	506	Identity:	191/506 - (37%)
Similarity:	288/506 - (56%)	Gaps:	88/506 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWY 85
            |.||::.|:.|.||||..|.|.:|||::::.|:.::||||..||::|:||||:|.:||||:..|.
Mouse    40 LSSAAKHEDSLFRDLFEDYEKWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWI 104

  Fly    86 DYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQS 150
            |.:|:|:..|||||.::|:|.|.:|.||||||:||||.:|......|:.| .|.|.|..||.|:|
Mouse   105 DVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGASTKTVVRY-NGTVTWTQPANYKS 168

  Fly   151 SCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYE 215
            |||||||:||||.|.|.|||||||::|.||.:.|.:..  ||.:|::.:|.|:|:..       .
Mouse   169 SCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQD--VDRTDFFDNGEWEIMSA-------M 224

  Fly   216 GDSNHPTET-----DITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISIL 275
            |...:.|::     .||:..:|:|..||||:.||:|.:.:|||.|:|||||:..|||::|..|:|
Mouse   225 GSKGNRTDSCCWYPCITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVL 289

  Fly   276 LSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHR-MPMYIRS 339
            :||.||||::.:|:|.:|.|:|||.:||:||.|..|:||:|||..||.:.|...||. |..::|.
Mouse   290 VSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRK 354

  Fly   340 IFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELS 404
            ||||.||..|.|:                   :|....:....|..|.    ||.:|:..:
Mouse   355 IFLHKLPKLLCMR-------------------SHADRYFTQREEAEKD----GGPKSRNTL---- 392

  Fly   405 DLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTR 469
                                                   ||  |.:.:.:|..|:..|:...:..
Mouse   393 ---------------------------------------EA--ALDCIRYITRHVVKENDVREVV 416

  Fly   470 EDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEIYRG 520
            ||||::|.|:||:.|:.|.:|:..||:|:.:  |.|:::.  :.|:.::.|
Mouse   417 EDWKFIAQVLDRMFLWTFLLVSIIGTLGLFV--PVIYKWA--NIIVPVHIG 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	187/484 (39%)
		Neur_chan_LBD	28..236	CDD:280998	97/212 (46%)
		Neur_chan_memb	243..498	CDD:280999	82/255 (32%)
Chrna5	NP_001360830.1	LGIC_ECD	45..251	CDD:355788	97/215 (45%)
Chrna5	NP_001360830.1	Neur_chan_memb	257..445	CDD:367256	82/255 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820