Protein Alignment nAChRbeta1 and Chrna3

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_660111.3
• Gene: Chrna3 / 110834
• MGIID: 87887
• Length: 499
• Species: Mus musculus
• Alignment Length: 509
• Identity: 219/509 - (43%)
• Similarity: 325/509 - (63%)
• Gaps: 53/509 - (10%)

  Fly    13 ILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSN 77
            :|||:...:.||||.|.||.:.||..||::||||.|::..|.::|.::..||:.|:|.||||::|
Mouse    14 MLVLMLLPVASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETN 78

  Fly    78 VWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLW 142
            :||:.:|.||:|:|..:||.|:..:|:|.:|:|||||||:|||||:::|..|:..|:..||||.|
Mouse    79 LWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTW 143

  Fly   143 VPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEV 207
            :||||::|||.|||||||||.|.|.||||||:::..::.|.|..:.  ::|.|||:||.|.||:.
Mouse   144 IPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSS--MNLKDYWESGEWAIIKA 206

  Fly   208 PAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGI 272
            |.|.:..:.:.......|||:.:.|||..||||:|||:|.:|||||.|||||||::.||||||.|
Mouse   207 PGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCI 271

  Fly   273 SILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYI 337
            |:||||.||||::::.:|.||||:|||.:|||||.|..|:||::||.::|.::|.|.||.||.::
Mouse   272 SVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWV 336

  Fly   338 RSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVME 402
            :::||:.||..:||.||..|.                       .:.||..:..|.:.|.:....
Mouse   337 KAVFLNLLPRVMFMTRPTSTE-----------------------EDAPKTRNFYGAELSNLNCFS 378

  Fly   403 LSD-----------------LHHPNCKINRKVNSGGELGLGDGCRRESESSDSIL----LSPEAS 446
            .:|                 .||...||:   |....|....    .|||.|::|    ||||..
Mouse   379 RADSKSCKEGYPCQDGTCGYCHHRRVKIS---NFSANLTRSS----SSESVDAVLSLSALSPEIK 436

  Fly   447 KATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            :|.::|::|||:::.:::..:.::|||||||||||:.|::|.:|...||.|:.:
Mouse   437 EAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	219/507 (43%)
		Neur_chan_LBD	28..236	CDD:280998	99/207 (48%)
		Neur_chan_memb	243..498	CDD:280999	107/275 (39%)
Chrna3	NP_660111.3	LIC	24..490	CDD:273305	216/497 (43%)
		LGIC_ECD_nAChR_A3	29..235	CDD:349817	99/207 (48%)
		Cys-loop	153..167	CDD:349817	11/13 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920