Protein Alignment nAChRbeta1 and Chrnb3

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_775304.1
• Gene: Chrnb3 / 108043
• MGIID: 106212
• Length: 464
• Species: Mus musculus
• Alignment Length: 499
• Identity: 194/499 - (38%)
• Similarity: 288/499 - (57%)
• Gaps: 64/499 - (12%)

  Fly     7 SWLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            ||    :.:.....|.|.:|.|:.|:|.||:||.|.:|||.|.:..:.|.|||...||::|:|||
Mouse    18 SW----VTLTATAGLSSVAEHEDALLRHLFQGYQKCVRPVLNSSDIIKVYFGLKISQLVDVDEKN 78

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136
            |:|.:||||:..|.|.:|:|:..|||||..:::|.:.:|.||||||.||||.:|....:..::..
Mouse    79 QLMTTNVWLKQEWTDQKLRWNPEDYGGINSIKVPSESLWLPDIVLFENADGRFEGSLMTKAIVKS 143

  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201
            :|.|.|.|||.|:||||:|||:||||:|.|.|||||||::|..|.|.|.|..  ||..|::.:|.
Mouse   144 SGTVSWTPPASYKSSCTMDVTFFPFDKQNCSMKFGSWTYDGTMVDLILINEN--VDRKDFFDNGE 206

  Fly   202 WDIIEVPAYL-NVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG 265
            |:|:...... |..||..::|.   :|:..::||..||||:.||:|.:.:|||.|||||||::.|
Mouse   207 WEILNAKGMKGNRREGFYSYPF---VTYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG 268

  Fly   266 EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT 330
            ||::|..|:|:||.||||::.:|:|.:|.|:|||.:||||..|..|:||:|||.:||.:.|...|
Mouse   269 EKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSST 333

  Fly   331 -HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGK 394
             |.|..:::.:||..||.:|.||.||..          .|.|                    .|.
Mouse   334 YHPMAPWVKRLFLEKLPRWLCMKDPRDR----------FSFP--------------------DGT 368

  Fly   395 QSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSD-SILLSPEASKATEAVEFIAEH 458
            :||                      |...|...|.::::.:|| ..:|.....||:|::.:|:.|
Mouse   369 ESK----------------------GTVRGKFPGKKKQTPTSDGERVLVAFLEKASESIRYISRH 411

  Fly   459 LRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502
            ::.|....|..:|||:||.|:||:.|::|...:..|:|.|.:.|
Mouse   412 VKKEHFISQVVQDWKFVAQVLDRIFLWLFLTASVLGSVLIFIPA 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	192/494 (39%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	95/209 (45%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
Chrnb3	NP_775304.1	LIC	6..455	CDD:455710	193/497 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..387		5/40 (13%)