Protein Alignment nAChRbeta1 and Chrnb4

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_683746.1
• Gene: Chrnb4 / 108015
• MGIID: 87892
• Length: 495
• Species: Mus musculus
• Alignment Length: 516
• Identity: 213/516 - (41%)
• Similarity: 309/516 - (59%)
• Gaps: 52/516 - (10%)

  Fly     9 LLCSILVLVAFSLVSASEDEERLVRDLFR--GYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            ||.|:..|:.......:..||:|:.||..  .||.||||..:.:|.:.:|..|:..|||:|||:.
Mouse     7 LLVSLFALLQPGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNERE 71

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136
            |||.:::||:..|.||:|.|:.:.|.|:.:||:|..:||.|||||:|||||.|||...:||::..
Mouse    72 QIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRS 136

  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201
            .|.:.|:|||||:|:|.|:|.:||||||.|.:||.|||::..::.:.|.:....:|  |:..||.
Mouse   137 NGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAIMD--DFTPSGE 199

  Fly   202 WDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGE 266
            |||:.:|....|...|   |:..|:|:..||:||.||||:|||:|.|||:.|.:||||||::.||
Mouse   200 WDIVALPGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGE 261

  Fly   267 KVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTH 331
            |:||.||:||:|..||||:|||:|||||.:|||.||||||.::.|.||:.||.::|.:.|.|.||
Mouse   262 KMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTH 326

  Fly   332 RMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPK----HI---- 388
            .|..:::..|||.||.||||||            ||:.:         |||.:|.    |:
Mouse   327 TMASWVKECFLHKLPTFLFMKR------------PGLEV---------SPARVPHSSQLHLTTAE 370

  Fly   389 ----SAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGD---GCRRESESSDSILLSPEAS 446
                ||:|....       |:|:..:......|.:..:..:..   |..|::....|.....:..
Mouse   371 ATSTSALGPSSP-------SNLYGNSMYFVNPVPATPKSAVSSHTAGLPRDARLRSSGRFRQDLQ 428

  Fly   447 KATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFE 507
            :|.|.|.|||:||.::|......||||:||||:|||.|::|.||...||:|:.:  |.:|:
Mouse   429 EALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVIVCILGTMGLFL--PPLFQ 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	211/507 (42%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	92/210 (44%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
Chrnb4	NP_683746.1	LIC	21..483	CDD:455710	207/496 (42%)
		LGIC_ECD	53..230	CDD:475126	79/181 (44%)