DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta1 and Chrnb4

DIOPT Version :9

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_683746.1 Gene:Chrnb4 / 108015 MGIID:87892 Length:495 Species:Mus musculus


Alignment Length:516 Identity:213/516 - (41%)
Similarity:309/516 - (59%) Gaps:52/516 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLCSILVLVAFSLVSASEDEERLVRDLFR--GYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            ||.|:..|:.......:..||:|:.||..  .||.||||..:.:|.:.:|..|:..|||:|||:.
Mouse     7 LLVSLFALLQPGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNERE 71

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136
            |||.:::||:..|.||:|.|:.:.|.|:.:||:|..:||.|||||:|||||.|||...:||::..
Mouse    72 QIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRS 136

  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201
            .|.:.|:|||||:|:|.|:|.:||||||.|.:||.|||::..::.:.|.:....:|  |:..||.
Mouse   137 NGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAIMD--DFTPSGE 199

  Fly   202 WDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGE 266
            |||:.:|....|...|   |:..|:|:..||:||.||||:|||:|.|||:.|.:||||||::.||
Mouse   200 WDIVALPGRRTVNPQD---PSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGE 261

  Fly   267 KVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTH 331
            |:||.||:||:|..||||:|||:|||||.:|||.||||||.::.|.||:.||.::|.:.|.|.||
Mouse   262 KMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTH 326

  Fly   332 RMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPK----HI---- 388
            .|..:::..|||.||.||||||            ||:.:         |||.:|.    |:    
Mouse   327 TMASWVKECFLHKLPTFLFMKR------------PGLEV---------SPARVPHSSQLHLTTAE 370

  Fly   389 ----SAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGD---GCRRESESSDSILLSPEAS 446
                ||:|....       |:|:..:......|.:..:..:..   |..|::....|.....:..
Mouse   371 ATSTSALGPSSP-------SNLYGNSMYFVNPVPATPKSAVSSHTAGLPRDARLRSSGRFRQDLQ 428

  Fly   447 KATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFE 507
            :|.|.|.|||:||.::|......||||:||||:|||.|::|.||...||:|:.:  |.:|:
Mouse   429 EALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVIVCILGTMGLFL--PPLFQ 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:273305 211/507 (42%)
Neur_chan_LBD 28..236 CDD:280998 92/209 (44%)
Neur_chan_memb 243..498 CDD:280999 108/269 (40%)
Chrnb4NP_683746.1 LIC 21..483 CDD:273305 207/496 (42%)
Neur_chan_LBD 26..231 CDD:280998 92/209 (44%)
Neur_chan_memb 238..481 CDD:280999 109/270 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
54.780

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