Protein Alignment nAChRbeta1 and chrna8

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_021329572.1
• Gene: chrna8 / 100537531
• ZFINID: ZDB-GENE-090313-161
• Length: 516
• Species: Danio rerio
• Alignment Length: 529
• Identity: 190/529 - (35%)
• Similarity: 295/529 - (55%)
• Gaps: 36/529 - (6%)

  Fly     2 ESSCKSWLLCSILVLVAFSLVSA--SEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQL 64
            :..|...|...|.:..:|.:..:  .|.:.:|.::|...||:|.|||.|.:..:.|..||..:|:
Zfish     4 KQKCFGILHLGIFIWTSFCIKGSLQGEYQRKLYKELMENYNRLERPVLNDSAPIVVELGLTLLQI 68

  Fly    65 INVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYK 129
            |:|:||||::.:|.||:|.|.|..|.|:..:|.|:..||.|.:::|.|||:|:|:||..::..:.
Zfish    69 IDVDEKNQVLITNAWLQLGWTDVYLSWNPDNYPGVQTLRFPSNQIWTPDILLYNSADERFDATFH 133

  Fly   130 SNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLS 194
            :|||:..:|...::||.|.:|:|.|||.:||||.|.|.:||||||.||..:.|.:    ..||:|
Zfish   134 TNVLVNASGACQYIPPGILKSTCYIDVRWFPFDIQKCDLKFGSWTHNGWLLDLQM----QAVDIS 194

  Fly   195 DYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFY 259
            .|..:|.||::.||...|....:.......|:||.:.:||:||:|.:||::|.||||.|.:|||.
Zfish   195 TYIPNGEWDLVGVPGKRNELYYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISGLALLVFL 259

  Fly   260 LPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWN 324
            |||::|||::|||::||||.||:|||::|:|.||..:||||:|...|.::..:|::|||:::.::
Zfish   260 LPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQFH 324

  Fly   325 FRGPRTHRMPMYIRSIFLHYLPAFLFMKRP---RKTRLRWMMEMPGMSMPAHPHPSYGS------ 380
            ...|:..:||.::|.|.|::...||.||:|   ||...::...      ||| |.|..|
Zfish   325 HHDPQGGKMPRWVRVILLNWCAWFLRMKKPGEERKANFKYDQS------PAH-HASASSIQMGVM 382

  Fly   381 PAELPKHISAIGGKQSKMEVMELSDLHH-------PNCKINRKVNSGGELGLGDGCRRESESSDS 438
            |.:.....|...|.      |.|...:|       |....:....|||.:| |.....:.|....
Zfish   383 PGQPSSTNSTTNGH------MNLYFGYHSIDSACCPPSSDSGVSCSGGRVG-GSPNEEQREGVRM 440

  Fly   439 ILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAP 503
            ....||..:....|.:||:..|::|.......:||:.|.|:|||.|..|.:.:...|..|||.||
Zfish   441 FAGEPEIHRILAEVMYIAQRFRDQDEAEAICSEWKFAAAVVDRLCLVAFSLFSIICTFTILMSAP 505

  Fly   504 HIFEYVDQD 512
            :..|.|.:|
Zfish   506 NFIEAVSKD 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	182/509 (36%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	82/208 (39%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
chrna8	XP_021329572.1	LIC	12..504	CDD:455710	183/509 (36%)