Protein Alignment nAChRbeta1 and LOC100537401

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_021333008.2
• Gene: LOC100537401 / 100537401
• -ID: -
• Length: 552
• Species: Danio rerio
• Alignment Length: 558
• Identity: 214/558 - (38%)
• Similarity: 311/558 - (55%)
• Gaps: 85/558 - (15%)

  Fly    11 CSILVLVAFSLVSASED---EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQ 72
            |..|:|:.:......::   ||||:..|...|:||.|||.:::..|.|.|||:..|||:|:||||
Zfish     4 CLHLLLLLYPAQVCCDEVQAEERLLNSLLSAYSKLTRPVHSVSDVVHVHFGLSIAQLIDVDEKNQ 68

  Fly    73 IMKSNVWLRLVWYDYQLQWDEA--DYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIY 135
            :|.:|||::..|.||:|:|...  |.|.:..:|:|...:|||||||:|||||::.|.:.:...:.
Zfish    69 MMTTNVWVKQEWLDYRLRWTPGPEDNGNVSSMRIPAQFIWKPDIVLYNNADGDFTVTHLTKAHLL 133

  Fly   136 PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSG 200
            ..|.|.|:|||||:|||:||||:.|||||.|.:||||||:  |:..:.|....:.||..|||:||
Zfish   134 HDGRVTWIPPAIYKSSCSIDVTFLPFDQQNCTIKFGSWTY--DRSKIDLIRIADSVDQLDYWESG 196

  Fly   201 TWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAG 265
            .|.|....|..||.:.:.......|||:..||||..||||:|||:|.:||..|.|||||||::.|
Zfish   197 EWLITSAVATYNVKKYECCSEEYADITYSFIIRRLPLFYTINLIIPCLLILCLTVLVFYLPSDCG 261

  Fly   266 EKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT 330
            |:||:.||:||||.|||||:::|:||||||:||||:||||..|...:.|::||.::|.:.|.|.|
Zfish   262 EEVTMCISVLLSLTVFLLLITEIIPPTSLVIPLIAEYLLFIMIFIILFIIITVFVLNVHHRSPDT 326

  Fly   331 HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQ 395
            |.||.::|..||..:|.|:|::||:    .|..:..|:...|.           ..:...:....
Zfish   327 HSMPQWVRRFFLDVMPRFIFIQRPQ----IWQKDAKGVCDDAQ-----------KSNKRCVDSNW 376

  Fly   396 SKMEVMELS------------DLHH-------------PNCKINR------KVNSG-GELGLGDG 428
            ...|:.|.|            |:|.             |..|:::      :||.| .::.|.:.
Zfish   377 KNREIKEESIRMKVYSSCLNADMHSIKSPSQAYNNSTCPKMKLHKGRSQSVQVNCGERDVNLCNS 441

  Fly   429 CRR------------ESESSDSILLSPE---------------ASKAT----EAVEFIAEHLRNE 462
            ..|            |.|...|.:.:.:               .|.||    |.|::|||:||.:
Zfish   442 STRFRSRSMQYCSLHEHEQQTSAVFNADKFSNICKVMTSTGENPSHATRLAIEGVQYIAEYLRAQ 506

  Fly   463 DLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            ...:..:|:|||||||||||.|::|.:|...|.||:.:
Zfish   507 HADLSVKEEWKYVAMVIDRLFLWMFVLVCILGIVGLFI 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	214/556 (38%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	98/213 (46%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
LOC100537401	XP_021333008.2	None