Protein Alignment nAChRbeta1 and chrnb4

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_012822341.1
• Gene: chrnb4 / 100497893
• XenbaseID: XB-GENE-985370
• Length: 481
• Species: Xenopus tropicalis
• Alignment Length: 516
• Identity: 223/516 - (43%)
• Similarity: 309/516 - (59%)
• Gaps: 51/516 - (9%)

  Fly     7 SWLLCSILVLVAFSLVSASEDEERLVRDLFR--GYNKLIRPVQNMTQKVGVRFGLAFVQLINVNE 69
            |.||..:..|:..:...|::.||||:.:|.|  .|||||||..|.:|.|.::..|:..|||:|||
 Frog     5 SSLLLLLTALLWVNCCKAADSEERLMNNLLRKDKYNKLIRPAYNNSQLVSIQLQLSLAQLISVNE 69

  Fly    70 KNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLI 134
            :.|||.:||||...|.||:|.|:.|||.||..||:|..::|.|||||:|||||.|||...:|.::
 Frog    70 REQIMTTNVWLNQEWVDYRLTWNPADYDGIKKLRIPSQQIWLPDIVLYNNADGTYEVSLFTNAIV 134

  Fly   135 YPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKS 199
            ...|.|.|:|||||:|:|.|:|.:||||||.|.:||.|||::..::.|.|  ||.:..:.|:..|
 Frog   135 QNNGSVAWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDYTEIDLVL--NKGWATMDDFTPS 197

  Fly   200 GTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA 264
            |.|||||:|....:...|   ||..|:|:..||:||.||||:|||:|.:||:.|.:||||||::.
 Frog   198 GEWDIIELPGRRTICPLD---PTYVDVTYDFIIKRKPLFYTINLIIPCILITSLAILVFYLPSDC 259

  Fly   265 GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPR 329
            |:|:||.||:||:|.|||||:|||:|||||.:|||.|||:||.::.|.||:.:|.::|.:.|.|.
 Frog   260 GQKMTLCISVLLALTVFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPS 324

  Fly   330 THRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGK 394
            ||.||.::::.||..||.|||||||..:                               ||....
 Frog   325 THTMPPWVKNCFLDRLPVFLFMKRPENS-------------------------------SASQKL 358

  Fly   395 QSKMEVMELSDLHHPNCKIN--------RKVNSGGELGLGDGCRRESESSDSILLSPEASKATEA 451
            :|....|::....:.|..:|        ..||...|    ....:|.........:||..:|.:.
 Frog   359 RSYRRNMQIESFRNSNYFVNMTTARPCDHTVNDPPE----SVRHQEFRYRYPRKYTPEVHEAMDG 419

  Fly   452 VEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQD 512
            |:||:||:::||......|||||||||:|||.|:||.||...||||:.|. |.|..:...|
 Frog   420 VKFISEHMKSEDEDQSIIEDWKYVAMVVDRLFLWIFIIVCIVGTVGLFMQ-PLIQNHTPPD 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	218/501 (44%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	103/210 (49%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
chrnb4	XP_012822341.1	LIC	21..468	CDD:455710	215/486 (44%)
		LGIC_ECD	53..230	CDD:475126	87/181 (48%)