Protein Alignment nAChRbeta1 and chrne

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_002941867.4
• Gene: chrne / 100497712
• XenbaseID: XB-GENE-979686
• Length: 505
• Species: Xenopus tropicalis
• Alignment Length: 524
• Identity: 170/524 - (32%)
• Similarity: 280/524 - (53%)
• Gaps: 75/524 - (14%)

  Fly    12 SILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKS 76
            |:|:|:..||.:.|| |.||::.||..|:...||.:.:...|.|...|....||::|||.:.:.:
 Frog     9 SLLILLHNSLANESE-ESRLIKYLFTNYDSKARPSKGIDDVVPVSLKLTLTNLIDLNEKEETLTT 72

  Fly    77 NVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVL 141
            |||:::.|.|.:|.|:|.:|||:.::::|.|.:|.|:|||.||.|||:||.|.:|||::.||.:.
 Frog    73 NVWVQIAWQDDRLTWNETEYGGMPLVQVPHDMMWLPEIVLENNIDGNFEVAYYANVLVHSTGYIY 137

  Fly   142 WVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNF--------VDLSDYWK 198
            |:||||::|:|:|::||||||.|.|.:.|.|.|::.:.:.|.|..:...        :|...:.:
 Frog   138 WLPPAIFRSTCSIEITYFPFDWQNCSLVFRSKTYSANDIDLHLVADDETGLPFDQVDIDREAFTE 202

  Fly   199 SGTWDIIEVPAYLNVYEGDSNHPTE-TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPA 262
            :|.|.|:..||...|....|..... .:|.|.:||:||.|||.:|:|:|.||||.|.|||::|||
 Frog   203 NGEWAIMHRPARKIVNPKYSKEDLRYQEIVFILIIQRKPLFYIINIIVPCVLISSLVVLVYFLPA 267

  Fly   263 EA-GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFR 326
            :| |:|.|:.||:||:..|||.|:::::|.|||.:|||.|||:|...::|:.:|..||::|.:.|
 Frog   268 KAGGQKCTVSISVLLAQTVFLFLIAQMIPETSLSVPLIGKYLMFVMFVSTLIVLSCVIVLNVSLR 332

  Fly   327 GPRTHRMPMYIRSIFLHYLPAFLFMK---------RPRKTRLRWMMEMPGMSMPAHPHPSYGSPA 382
            .|.||.:...::.:.|..||.|:.::         .||:.|                ..|.|...
 Frog   333 SPSTHTLSSKVKHMLLEVLPQFIHLRVEPCDEGEETPRERR----------------RSSLGIML 381

  Fly   383 ELPKHISAIGGKQSKMEVM-ELSDLHHPNCKINRKVNSGGELGLGDGCRRESES--SDSI----- 439
            :..:::.    |:.:.|:| |.....|                   |.|||.:.  :|..
 Frog   382 KAEEYVL----KKPRSELMFERQRERH-------------------GMRREPDGYRADGFDVGVT 423

  Fly   440 --------LLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTV 496
                    ..:||.....:|..||.::.::::......|:|..:..|:|.|..::...:...||:
 Frog   424 TTLYRNLAQCAPEIKDCVDACNFITQNTKDDNATGAEMENWVLIGKVLDVLCFWVALPLFVLGTL 488

  Fly   497 GILM 500
            .|.:
 Frog   489 AIFL 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	170/522 (33%)
		Neur_chan_LBD	28..236	CDD:280998	81/216 (38%)
		Neur_chan_memb	243..498	CDD:280999	76/280 (27%)
chrne	XP_002941867.4	LGIC_ECD_nAChR_G	47..241	CDD:349830	73/193 (38%)
		Neur_chan_memb	248..491	CDD:397193	76/281 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910