Protein Alignment nAChRbeta1 and chrna2

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_004914998.2
• Gene: chrna2 / 100495873
• XenbaseID: XB-GENE-1013893
• Length: 510
• Species: Xenopus tropicalis
• Alignment Length: 525
• Identity: 235/525 - (44%)
• Similarity: 324/525 - (61%)
• Gaps: 53/525 - (10%)

  Fly     4 SCKSWLLCSILVLVAFSLVSASE-----DEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQ 63
            :|....|..:..::.|:.||..|     .||||.:.||.|||:..|||.|.:..|.|:|||:..|
 Frog     3 NCMGGTLSILCWMITFTTVSCMERTRTHAEERLFKRLFTGYNRWSRPVPNTSDVVIVKFGLSIAQ 67

  Fly    64 LINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRY 128
            ||:|:||||:|.:||||:..|.||:|:|:.|||..:..:|:|.:.:|.|||||:|||||.:.:.:
 Frog    68 LIDVDEKNQMMTTNVWLKQEWNDYKLRWNPADYDNVTSIRVPSEMIWIPDIVLYNNADGEFAITH 132

  Fly   129 KSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDL 193
            .:...::..|:|.|||||||:|||:||||:||||||:|.|||||||:  |:..|.|.:.:..|||
 Frog   133 MTKAHLFHNGKVKWVPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTY--DKAWLDLESMERNVDL 195

  Fly   194 SDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVF 258
            .|||:||.|.|:......|..:.|.......|||:|.||||..||||:|||:|.:|||.|.||||
 Frog   196 KDYWESGEWAIVNAVGKYNSKKYDCCTEIYPDITYYFIIRRLPLFYTINLIIPCLLISCLTVLVF 260

  Fly   259 YLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINW 323
            |||::.|||:||.||:||||.|||||:::|:|.||||:|||.:|||||.|..|:||::||.::|.
 Frog   261 YLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNV 325

  Fly   324 NFRGPRTHRMPMYIRSIFLHYLPAFLFMKRP----------------RKTRLRWMMEMPGMSMPA 372
            :.|.|.||:||:::||:||.::|.:||||||                :.:..::.||.......|
 Frog   326 HHRSPSTHKMPLWVRSVFLDHIPRWLFMKRPPAPVEEVVSQYDAPELKLSTSKYWMETDVDDKWA 390

  Fly   373 HPHPSYGSPAELP----KHISAIGGKQSKMEVMELSDLHHPNCKINRKVN---SGGELGLGDGCR 430
            .|.      |||.    :|::.                |:.:.:.....|   |||:........
 Frog   391 EPE------AELQTCHVRHMTT----------------HNQSLQYRYDYNHHVSGGQSQTPRHSS 433

  Fly   431 RESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGT 495
            .|:..| |.||||...||.|.|.:||.|||.||.....:||||||||||||:.|::|.||...||
 Frog   434 TETAES-SFLLSPSVLKALEGVHYIANHLRAEDADFSVKEDWKYVAMVIDRIFLWMFIIVCLLGT 497

  Fly   496 VGILM 500
            ||:.:
 Frog   498 VGLFL 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	234/519 (45%)
		Neur_chan_LBD	28..236	CDD:280998	105/207 (51%)
		Neur_chan_memb	243..498	CDD:280999	118/277 (43%)
chrna2	XP_004914998.2	LIC	9..503	CDD:273305	234/519 (45%)
		LGIC_ECD_nAChR_A2	32..238	CDD:349816	105/207 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920