DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta1 and chrna6

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_031759256.1	Gene:	chrna6 / 100495287	XenbaseID:	XB-GENE-6033398	Length:	488	Species:	Xenopus tropicalis

Alignment Length:	501	Identity:	201/501 - (40%)
Similarity:	321/501 - (64%)	Gaps:	30/501 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESSCKSWLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLIN 66
            :|.|  :||.::|.::..||  ..|.||:|.:.|...||:.||||:|::..|.|.|.:|..||:|
Frog     9 KSFC--FLLLTLLAVLKGSL--QCETEEKLFQKLLARYNQHIRPVENVSDPVMVHFEVAITQLVN 69

  Fly    67 VNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSN 131
            |:|.|||:::|:|||.:|.||:|||:..:|.||..:|:|.||:|||||||:|||.|:::|..||.
Frog    70 VDEVNQILETNLWLRHIWNDYKLQWNPEEYDGIEFMRIPADKIWKPDIVLYNNAVGDFQVEGKSK 134

  Fly   132 VLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDY 196
            .|:...|.:.|.||||::|||.:|:|:||||.|.|.||||||:::..::.||:..:|  ||:.|:
Frog   135 ALVKYNGLITWSPPAIFKSSCPMDITFFPFDHQNCSMKFGSWSYDKAKIDLAIIGSK--VDMKDF 197

  Fly   197 WKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLP 261
            |::..|:|::...:.:..:.:......||||:...|||..:|||:|||:|.:.:|||.|||||||
Frog   198 WENSEWEIVDASGFKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIMPCLFLSFLTVLVFYLP 262

  Fly   262 AEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFR 326
            ::.||||||.||:||||.||||::::.:|.||||:||:.:|||||.|..|:||:|||.::|.::|
Frog   263 SDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYR 327

  Fly   327 GPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAI 391
            .|.||:|||:::.:||..||..|.||:..:.:.|             |:..........|....:
Frog   328 TPTTHKMPMWVKDVFLKRLPKLLMMKKTVEKKNR-------------PYSKQNRKKSCEKSSELV 379

  Fly   392 GGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSIL--LSPEASKATEAVEF 454
            ..:.:::|..|....:|  |..:::.:|...       ||:...|:..:  .|.|.::..::::|
Frog   380 DSESAEVEQFEDESCYH--CMRSKEQSSRVR-------RRQQRDSNGAVQECSSELTEVVDSIQF 435

  Fly   455 IAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            :|.::|:.:...:..:|||||||||||:.|::|.::...||.|:.:
Frog   436 MAGNIRDHNERKEEEDDWKYVAMVIDRVFLWVFILLCVVGTTGLFL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	199/493 (40%)
		Neur_chan_LBD	28..236	CDD:280998	94/207 (45%)
		Neur_chan_memb	243..498	CDD:280999	94/256 (37%)
chrna6	XP_031759256.1	LIC	29..481	CDD:273305	194/475 (41%)
chrna6	XP_031759256.1	LGIC_ECD	31..237	CDD:355788	94/207 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110